FORMULATION AND EVALUATION OF PIROXICAM FAST DISSOLVING TABLETS USING DIFFERENT NATURAL SUPERDISINTEGRANTS

  • Praveen Kumar Nagar Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India
  • Parvez Nayyar Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India
  • Pramod K Sharma Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India
DOI https://doi.org/10.22270/jddt.v4i4.929

Abstract

The demand for fast dissolving tablets has been growing during the last decade, especially for geriatric and pediatric patients who have swallowing rapidly. Piroxicam is a potent anti-inflammatory drug used in treatment of osteoarthritis, rheumatoid arthritis, ankylosing Spondylitis and acute gout disease. In the present work, 9 formulations of fast dissolving

Tablets of Piroxicam (F1 to F9) were prepared using three different Superdisintegrants namely isapghula, fenugreek and guar gum with three concentrations (4%, 5% and 6%) and a control F10 (without superdisintegrant) by direct compression method. The final blend of the drug and excipients were evaluated for powder flow properties, bulk density, tapped density, compressibility index and hausner’s ratio. All the formulations were evaluated for thickness, weight variation, disintegration time, hardness, friability. Formulation F7 showed the lowest disintegration time. In-vitro dissolution studies revealed that formulation F4 showed 99.18 % percent drug release at the end of 60 minutes.

Keywords: Anti-inflammatory, Direct compression, fast dissolving, Piroxicam,      Superdisintegrant

Downloads

Download data is not yet available.
Statistics
107 Views | 337 Downloads
How to Cite
Nagar, P., Nayyar, P., & Sharma, P. (2014). FORMULATION AND EVALUATION OF PIROXICAM FAST DISSOLVING TABLETS USING DIFFERENT NATURAL SUPERDISINTEGRANTS. Journal of Drug Delivery and Therapeutics, 4(4), 55-59. https://doi.org/10.22270/jddt.v4i4.929
Issue
Vol 4 No 4 (2014): Volume 4, Issue 4, July-August, 2014
Section
Research

Authors who publish with this journal agree to the following terms:

 

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.

 

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

 

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Â