AN EXPERIMENTAL STUDY TO EVALUATE PROTECTIVE EFFECTS OF NAPROXEN AND VALDECOXIB ON NAPHTHALENE INDUCED CATARACT IN ALBINO RATS

  • Anjan Khadka AFMC
  • Dick BS Brashier AFMC
  • Ashok Kumar Sharma
  • Navdeep Dahiya
  • Ajay K Gupta
  • Sushil Sharma

Abstract

Background:The role of non-steroidal anti-inflammatory drugs (NSAIDs) in cataract formation is still unclear, previous data has indicated a cataractogenic as well as a potential protective effect of NSAIDs against cataract formation. Anti-cataract efficacy of NSAIDs have been studied extensively in different experimental settings. In view of this naproxen is used as standard and valdecoxib, a COX II (cyclooxygenase II) inhibitor is used as drug for comparison to evaluate the protective effects on naphthalene induced cataract in albino rats.

Objective: The objective of the present study was to evaluate the effects of naproxen and valdecoxib on naphthalene induced cataract in albino rats.

Materials and methods: Thirty-six adult albino rats were taken and divided into six groups containing six animals each. Group I (control) received normal saline orally.  Group II (control) received normal saline eye drops. Group III received naproxen (4mg/kg) orally. Group IV received naproxen eye drops (2%). Group V received valdecoxib (3mg/kg) orally. Group VI received valdecoxib eye drops (2%). Oral dose and eye drops were given daily for 10 days prior to induction of cataract. Cataract was induced by oral administration of naphthalene 1gm/kg in albino rats. Rats were examined daily for appearance of lenticular capacity by indirect illumination, direct ophthalmoscopy, slit lamp examination, and observed for any mortality for period of thirty days.

Conclusion: Naproxen is more efficacious than valdecoxib a COX II selective inhibitor in retarding progress of cataract induced by naphthalene.

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Author Biography

Anjan Khadka, AFMC
Pharmacology
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How to Cite
1.
Khadka A, Brashier D, Sharma A, Dahiya N, Gupta A, Sharma S. AN EXPERIMENTAL STUDY TO EVALUATE PROTECTIVE EFFECTS OF NAPROXEN AND VALDECOXIB ON NAPHTHALENE INDUCED CATARACT IN ALBINO RATS. JDDT [Internet]. 14Jul.2014 [cited 30May2020];4(4):34-7. Available from: http://jddtonline.info/index.php/jddt/article/view/923