AN EXPERIMENTAL STUDY TO EVALUATE PROTECTIVE EFFECTS OF NAPROXEN AND VALDECOXIB ON NAPHTHALENE INDUCED CATARACT IN ALBINO RATS

  • Anjan Khadka AFMC
  • Dick BS Brashier AFMC
  • Ashok Kumar Sharma
  • Navdeep Dahiya
  • Ajay K Gupta
  • Sushil Sharma

Abstract

Background:The role of non-steroidal anti-inflammatory drugs (NSAIDs) in cataract formation is still unclear, previous data has indicated a cataractogenic as well as a potential protective effect of NSAIDs against cataract formation. Anti-cataract efficacy of NSAIDs have been studied extensively in different experimental settings. In view of this naproxen is used as standard and valdecoxib, a COX II (cyclooxygenase II) inhibitor is used as drug for comparison to evaluate the protective effects on naphthalene induced cataract in albino rats.

Objective: The objective of the present study was to evaluate the effects of naproxen and valdecoxib on naphthalene induced cataract in albino rats.

Materials and methods: Thirty-six adult albino rats were taken and divided into six groups containing six animals each. Group I (control) received normal saline orally.  Group II (control) received normal saline eye drops. Group III received naproxen (4mg/kg) orally. Group IV received naproxen eye drops (2%). Group V received valdecoxib (3mg/kg) orally. Group VI received valdecoxib eye drops (2%). Oral dose and eye drops were given daily for 10 days prior to induction of cataract. Cataract was induced by oral administration of naphthalene 1gm/kg in albino rats. Rats were examined daily for appearance of lenticular capacity by indirect illumination, direct ophthalmoscopy, slit lamp examination, and observed for any mortality for period of thirty days.

Conclusion: Naproxen is more efficacious than valdecoxib a COX II selective inhibitor in retarding progress of cataract induced by naphthalene.

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Author Biography

Anjan Khadka, AFMC
Pharmacology
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How to Cite
Khadka, A., Brashier, D., Sharma, A., Dahiya, N., Gupta, A., & Sharma, S. (2014). AN EXPERIMENTAL STUDY TO EVALUATE PROTECTIVE EFFECTS OF NAPROXEN AND VALDECOXIB ON NAPHTHALENE INDUCED CATARACT IN ALBINO RATS. Journal of Drug Delivery and Therapeutics, 4(4), 34-37. https://doi.org/10.22270/jddt.v4i4.923