AN EXPERIMENTAL STUDY TO EVALUATE PROTECTIVE EFFECTS OF NAPROXEN AND VALDECOXIB ON NAPHTHALENE INDUCED CATARACT IN ALBINO RATS
Background:The role of non-steroidal anti-inflammatory drugs (NSAIDs) in cataract formation is still unclear, previous data has indicated a cataractogenic as well as a potential protective effect of NSAIDs against cataract formation. Anti-cataract efficacy of NSAIDs have been studied extensively in different experimental settings. In view of this naproxen is used as standard and valdecoxib, a COX II (cyclooxygenase II) inhibitor is used as drug for comparison to evaluate the protective effects on naphthalene induced cataract in albino rats.
Objective: The objective of the present study was to evaluate the effects of naproxen and valdecoxib on naphthalene induced cataract in albino rats.
Materials and methods: Thirty-six adult albino rats were taken and divided into six groups containing six animals each. Group I (control) received normal saline orally.Â Group II (control) received normal saline eye drops. Group III received naproxen (4mg/kg) orally. Group IV received naproxen eye drops (2%). Group V received valdecoxib (3mg/kg) orally. Group VI received valdecoxib eye drops (2%). Oral dose and eye drops were given daily for 10 days prior to induction of cataract. Cataract was induced by oral administration of naphthalene 1gm/kg in albino rats. Rats were examined daily for appearance of lenticular capacity by indirect illumination, direct ophthalmoscopy, slit lamp examination, and observed for any mortality for period of thirty days.
Conclusion: Naproxen is more efficacious than valdecoxib a COX II selective inhibitor in retarding progress of cataract induced by naphthalene.
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