FORMULATION AND EVALUATION OF MUCOADHESIVE GASTRO RETENTIVE TABLET OF LEVAMISOLE BY USING PURIFIED POLYSACCHARIDE ISOLATED FROM TERMINALIA BELLERICA GUM

  • Biswajit Das Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati 781017, Assam, India
  • Suvakanta Dash Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati 781017, Assam, India
  • Ramesh Chandra Choudhury Department of Zoology, Berhampur University, Berahampur 760007, Odisha, India
  • Jashabir Chakraborty Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati 781017, Assam, India
DOI https://doi.org/10.22270/jddt.v4i4.914

Abstract

The present investigation deals with the development of mucoadhesive gastro retensive tablets of levamisole using polysaccharide isolated from Terminalia bellerica gum (TBG). The TBG polysaccharide was tested for acute toxicity and drug–excipient compatibility study. The tablet formulations with TBG were evaluated for physical characteristics like hardness, % friability, % drug content and weight variations. Dissolution study was conducted to characterize release mechanism of the formulation and data are fitted to various kinetic models. The mucoadhesive abilities were studied by different in vitro, Ex vivo and in vivo models. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in the case of Korsemeyer–Peppas model and the release mechanism study proved that the formulation showed a combination of diffusion and erosion processes. The mucoadhesive properties of polysaccharide are comparable to synthetic polymer in all Ex vivo, in vitro and in vivo models.  There was a significant difference in the pharmacokinetic parameters (Tmax, Cmax, AUC0-∞, AUC0-t, AUMC, MRT, T1/2, Ka and Kel) of the optimized formulation as compared to standard marketed formulation, which proves the controlled release and mucoadhesive property of the isolated polysaccharide.

Keywords- TBG polysaccharide, Scintigraphic,  X-Ray study, Korsemeyer–Peppas model

Downloads

Download data is not yet available.
Statistics
229 Views | 289 Downloads
How to Cite
1.
Das B, Dash S, Choudhury R, Chakraborty J. FORMULATION AND EVALUATION OF MUCOADHESIVE GASTRO RETENTIVE TABLET OF LEVAMISOLE BY USING PURIFIED POLYSACCHARIDE ISOLATED FROM TERMINALIA BELLERICA GUM. JDDT [Internet]. 14Jul.2014 [cited 10Aug.2022];4(4):24-3. Available from: http://jddtonline.info/index.php/jddt/article/view/914
Issue
Vol 4 No 4 (2014): Volume 4, Issue 4, July-August, 2014
Section
Research

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).