NOVEL SYNTHESIS OF PEG COATED IRON NANOPARTICLES (Fe3O4) AND ITâ€™S EVALUATION OF CONTROLLED RELEASE KINETICS IN DRUG DELIVERY SYSTEM
Magnetic Nanoparticles (MNPs) because of their high magnetic responsiveness, biodegradability, high delivery efficiency and potential targeting function is a possible material as drug delivery system, since Â drug â€“loaded MNPs can be directly injected in to solid tumors and Â Â are expected to be held in place by an external magnetic field and to release the drug in a controlled manner. In the present research study Synthesis, Characterization and in vitro rate studies of super paramagnetic Iron Nanoparticles coated with PEG has been carried out. The nanoparticle synthesized in the present study had an average particle size of ~ 30 nm. starch-based polysaccharide nanocarrier encapsulated with the drug i.e. THC and MNPs as anticancer drug delivery was constructed. This efficiently reduces tumor growth thus providing a proof of concept for the utilization of this formulation in cannabinoid-based anti-cancer therapies. Evaluation of THC loaded magnetic nanoparticles was successfully carried out and correlation coefficient (R2) value 0.999 and drug released was found to be 97% for 48hrs at pH7.0. The entrapment efficiency and drug loading of THC-MNPs in the starch based nanoparticles was found to be high.Â
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