DISSOLUTION BEHAVIOUR OF DICLOFENAC POTASSIUM USING DUAL RELEASE SPHEROIDS
The objective of the present work was attempted to formulate a dual release drug delivery system comprising immediate release and delayed release pattern using solid dispersion and pellets of diclofenac potassium and to achieve a customized in vitro profile for developed formulation. Diclofenac potassium is chosen as a model drug, as it is classified under BCS-II with low solubility, an attempt was made to increase solubility with solid dispersion. Lactose is selected as a carrier. Solid dispersion is made with concentrations of carrier ratios (1:1,1:2,1:3,1:4,1:5). It was evident that in vitro drug release of the optimised batch (SD4) shows promising increase of solubility same is taken for the further studies to prepare a dual release dosage form as a immediate release formulation. Sustain release spheroids was formulated with different concentrations of polymer HPMC K 100M.The results revealed that all the values are within the range formulation D3 was selected as an ideal batch for further studies to prepare a dual release dosage form as a sustained release formulation based on the in vitro performance. The dual release dosage form was constructed using the optimized batches from solid dispersion (SD4) and pellets (D3). The prepared dual release dosage form was evaluated for in vitro release studies The release models were plotted in the dual release dosage form .It was observed that the developed dual releaseÂ spheroids follow first order kinetics obeying fickian diffusion.Keywords: Pellets, Solid dispersion, Diclofenac potassium, HPMC
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