A Review on Liquisolid Systems

  • Nilesh Prakashchandra Kala K. B. Institute of Pharmaceutical Education and Research
  • Mohammadsalman Tamizuddin Shaikh K. B. Institute of Pharmaceutical Education and Research
  • Divyesh H Shastri K. B. Institute of Pharmaceutical Education and Research
  • Pragna K Shelat K. B. Institute of Pharmaceutical Education and Research

Abstract

Solubility & dissolution rate enhancement from solid oral dosage form is a key issue for current formulation and development. This review discusses, out of several techniques available, liquisolid system to improve dissolution rate of water insoluble drugs and to enhance dissolution rate of water soluble drugs. Different carriers and coating materials like Fujicalin®, Neusilin®, Avicel®, and Aerosil® can be used as carrier materials to prepare liquisolid system. Various non-volatile solvents like propylene glycol, liquid polyethylene glycols, polysorbates, glycerine, N,N-dimethylacetamide and fixed oils can be used to dissolve water insoluble molecules. Liquid drugs can be mixed directly with carriers to produce liquisolid systems. Liquisolid systems can be used to either enhance or retard drug release.

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Author Biographies

Nilesh Prakashchandra Kala, K. B. Institute of Pharmaceutical Education and Research
P.G. Student, Department of Pharmaceutics
Mohammadsalman Tamizuddin Shaikh, K. B. Institute of Pharmaceutical Education and Research
P.G. Student, Department of Pharmaceutics
Divyesh H Shastri, K. B. Institute of Pharmaceutical Education and Research
Assistant Professor, Department of Pharmaceutics
Pragna K Shelat, K. B. Institute of Pharmaceutical Education and Research
Professor, Department of Pharmaceutics
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How to Cite
1.
Kala N, Shaikh M, Shastri D, Shelat P. A Review on Liquisolid Systems. JDDT [Internet]. 15May2014 [cited 27Nov.2021];4(3):25-1. Available from: http://jddtonline.info/index.php/jddt/article/view/828