PHARMACOLOGICAL INVESTIGATION ON METHANOLIC EXTRACT OF LEAVES OF Diospyros peregrina GURKE ON ALLOXAN INDUCED HYPERGLYCEMIA IN RATS
Diospyros peregrina, commonly known as Kalatendu, is widely used in different parts of India for the treatment of diabetes mellitus. The present study was designed to evaluate the antihyperglycemic effect of a methanolic extract of Diospyros peregrina leaves (DPLE) in alloxan diabetic rats. Hyperglycemia was induced by single intravenous injection of alloxan (70mg/kg body weight). The extract was administered orally at a dose of 100, 200 and 400 mg/kg body weight, to normal and alloxan diabetic rats. No effect of the extract was observed in normal rats. Significant effect of the extract was observed in alloxan diabetic rats. Metformin was the reference drug used in the experiments. Glucose tolerance test was also performed. The studies indicate that the crude extract exhibited statistically significant antihyperglycemic activities in glucose tolerance test and alloxan induced diabetic rats.
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