2D QSAR STUDIES ON THE DIFFERENTIAL INHIBITION OF ALDOSE REDUCTASE BY FLAVONIODS COMPOUNDS:A COMPARATIVE STUDY

  • Mamta Arora Computer Aided Drug Discovery Department, ASBASJSMCOP, Bela Ropar Punjab,India 140111
  • M N Noolvi Computer Aided Drug Discovery Department, ASBASJSMCOP, Bela Ropar Punjab,India 140111
  • Harun Patel Computer Aided Drug Discovery Department, ASBASJSMCOP, Bela Ropar Punjab,India 140111

Abstract

A quantitative structure activity relationship study of  66 molecules was performed using MLR(Multiple Linear Regression) and PCR (Principal component Analysis) of aldose reductase by flavonoids compounds.Various descriptors, topological indices were used to characterize flavonoids molecules.In the developed model MLR is giving vary significant results wheras PCR  has revealed some important information.

Keywords: Flavonoids, aldose reuctase, QSAR, Multiple Linear Regression, Principle Component Regression

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Arora M, Noolvi M, Patel H. 2D QSAR STUDIES ON THE DIFFERENTIAL INHIBITION OF ALDOSE REDUCTASE BY FLAVONIODS COMPOUNDS:A COMPARATIVE STUDY. JDDT [Internet]. 14Mar.2014 [cited 30Nov.2020];4(2):39-2. Available from: http://jddtonline.info/index.php/jddt/article/view/790