2D QSAR STUDIES ON THE DIFFERENTIAL INHIBITION OF ALDOSE REDUCTASE BY FLAVONIODS COMPOUNDS:A COMPARATIVE STUDY
A quantitative structure activity relationship study ofÂ 66 molecules was performed using MLR(Multiple Linear Regression) and PCR (Principal component Analysis) of aldose reductase by flavonoids compounds.Various descriptors, topological indices were used to characterize flavonoids molecules.In the developed model MLR is giving vary significant results wheras PCRÂ has revealed some important information.
Keywords: Flavonoids, aldose reuctase, QSAR, Multiple Linear Regression, Principle Component Regression
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