SYNTHESIS, CHARACTERIZATION AND BILOGICAL SCREENING OF SOME NOVEL INDOLE BASED 1,2,4-TRIAZOLO 1,3,4-THIADIAZINES

  • Raghu Vardhan Reddy Mekala Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, India.
  • Mahipal Reddy Yata Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, India.
  • Ravi Prasad Talagadadivi Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, India.

Abstract

A series of novel 3-(1H-indole-4-yl)-6-aryl-7H-[1,2,4]-triazolo-[3,4-b][1,3,4]-thiadiazines (6a-f) were synthesized by involving 1H-indole-4-carboxylic acid (1) as raw material and 1H-indole-4-carboxylic acid ethyl ester (2), 1H-indole-4-carboxylic acid hydrazide (3), 5-(1H-indole-4-yl)-[1,3,4]oxadiazole-2-thiol (4) and 4-amino-5-(1H-indol-4-yl)-4H-[1,2,4]-triazole-3-thiol (5)as intermediates. The chemical structures of the all newly synthesized compounds were elucidated by their IR, 1H and 13 C NMR, mass spectral data and elemental analysis. Further, the target compounds were used to find their antifungal and nematicidal activity.

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Author Biographies

Raghu Vardhan Reddy Mekala, Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, India.
Assistant professor, Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, India.
Mahipal Reddy Yata, Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, India.
Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, India.
Ravi Prasad Talagadadivi, Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, India.
Department of Chemistry, Kakatiya University, Warangal, Andhra Pradesh, India.
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How to Cite
1.
Mekala R, Yata M, Talagadadivi R. SYNTHESIS, CHARACTERIZATION AND BILOGICAL SCREENING OF SOME NOVEL INDOLE BASED 1,2,4-TRIAZOLO 1,3,4-THIADIAZINES. JDDT [Internet]. 14Mar.2014 [cited 19Sep.2020];4(2):43-6. Available from: http://jddtonline.info/index.php/jddt/article/view/786