FORMULATION AND EVALUATION OF TASTE MASKED ORAL SUSPENSION OF CHLOROQUINE PHOSPHATE
AbstractThe purpose of this research was to mask the intensely bitter taste of Chloroquine phosphate using ion exchange resin and to formulate oral suspension of the taste masked drug. Batch method was used for formation of drug resin complex. Various ion exchange resins such as Doshion P 544 S and Kyron T- 114 were tried to obtained taste masked drug resin complex (DRC). Optimization of drug loading was carried out. With Doshion P 544 S, the drug-resin proportion of 1:4 achieved equilibrium in 5 hours. 96% w/w of drug loading was possible by this method. Complex formation was confirmed by DSC and IR studies. Oral taste masked suspension was prepared using xanthum gum at various concentrations 0.1%, 0.2% and 0.4% respectively. CPR 1 and CPR 2 batches showed satisfactory assay result that is it fulfills the official requirements. But physical properties of suspension were not satisfactory. CPR 1 was not easily redispersible and with CPR 2 caking was observed with sedimentation volume of 0.4, hence these batches were rejected. CPR 3 was found to be optimized batch as it showed complied assay results were found to be easily redispersible even after 7 days with no cake formation and sedimentation volume of 0.98. and was evaluated for various parameters such as Colour, pH, Viscosity etc. Thus, successful taste masking and formulation of suspension with taste masked drug especially for pediatric, geriatric, and non cooperative patients.
Download data is not yet available.
437 Views | 756 Downloads
How to Cite
Bafna A. FORMULATION AND EVALUATION OF TASTE MASKED ORAL SUSPENSION OF CHLOROQUINE PHOSPHATE. JDDT [Internet]. 14Mar.2014 [cited 17Oct.2021];4(2):16-4. Available from: http://jddtonline.info/index.php/jddt/article/view/769
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).