DEVELOPMENT AND PHYSICO-CHEMICAL EVALUATION OF MONOLITHIC MATRIX TYPE TRANSDERMAL FILMS OF AMMONIA METHACRYLATE COPOLYMER-METHOCEL AND METHACRYLIC ACID COPOLYMER-METHOCEL OF A MODEL ANTI-HYPERTENSIVE DRUG

  • Mithun Bhowmick Dept. of Pharmaceutics, Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, India *C
  • Tamizharasi Sengodan Dept. of Pharmaceutics, Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, India *C
  • Sivakumar Thangavel Dept. of Pharmaceutics, Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, India *C

Abstract

The main challenge of the present study is to effectively design a Monolithic Matrix type of transdermal films with the use of binary blends of polymers (Methacrylic Acid Copolymer: Acrylcoat S100 & Acrylcoat L100-Methocel K15M and Ammonia Methacrylate Copolymer: Eudragit RSPO & Eudragit RLPO-MK15M and use of most appropriate plasticizer: hydrophilic such as Polyethylene glycol 400 & Propylene Glycol or hydrophobic such as Dibutyl phthalate (DBT) & Dibutyl sebacate for that particular combination of polymers so that a good film can be obtained. In this research work, 2 different permeation enhancers of Terpene class such as d- limonene and 1,8 cineole in combination were used. The Physico-chemical properties of patches determined for the suitability and acceptability of the prepared patches. The thickness, weight, tensile strength, % elongation, folding endurance and flatness were determined for the prepared patches. We found good and acceptable Physicochemical parameters of the matrix films regarding properties and performance.

Keywords: Transdermal, Monolithic, Matrix films, Physico-chemical properties

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Bhowmick M, Sengodan T, Thangavel S. DEVELOPMENT AND PHYSICO-CHEMICAL EVALUATION OF MONOLITHIC MATRIX TYPE TRANSDERMAL FILMS OF AMMONIA METHACRYLATE COPOLYMER-METHOCEL AND METHACRYLIC ACID COPOLYMER-METHOCEL OF A MODEL ANTI-HYPERTENSIVE DRUG. JDDT [Internet]. 8Jan.2014 [cited 1Dec.2021];4(1):5-4. Available from: http://jddtonline.info/index.php/jddt/article/view/752