DEVELOPMENT AND PHYSICO-CHEMICAL EVALUATION OF MONOLITHIC MATRIX TYPE TRANSDERMAL FILMS OF AMMONIA METHACRYLATE COPOLYMER-METHOCEL AND METHACRYLIC ACID COPOLYMER-METHOCEL OF A MODEL ANTI-HYPERTENSIVE DRUG
The main challenge of the present study is to effectively design a Monolithic Matrix type of transdermal films with the use of binary blends of polymers (Methacrylic Acid Copolymer: Acrylcoat S100 & Acrylcoat L100-Methocel K15M and Ammonia MethacrylateÂ Copolymer: Eudragit RSPO & Eudragit RLPO-MK15M and use of most appropriate plasticizer: hydrophilic such as Polyethylene glycol 400 & Propylene Glycol or hydrophobic such as Dibutyl phthalate (DBT) & Dibutyl sebacate for that particular combination of polymers so that a good film can be obtained. In this research work, 2 different permeation enhancers of Terpene class such as d- limonene and 1,8 cineole in combination were used. The Physico-chemical properties of patches determined for the suitability and acceptability of the prepared patches. The thickness, weight, tensile strength, % elongation, folding endurance and flatness were determined for the prepared patches. We found good and acceptable Physicochemical parameters of the matrix films regarding properties and performance.
Keywords: Transdermal, Monolithic, Matrix films, Physico-chemical properties
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).