MODIFIED NATURAL CARRIER IN SOLID DISPERSION FOR ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE DRUGS

  • Amar Anantrao Shejul Department of Pharmaceutics, Anuradha colleege of pharmacy, Sakegaon road ,Chikhali,Dist Buldana
  • Subhash Deshmane
  • Kailas Biyani

Abstract

The solid dispersion is one of the most important and desirable technique of solubility enhancement, the use of natural carrier in solid dispersion gives prominent and ecofriendly results. Many carriers have limitations in enhancing solubility of poorly water soluble drugs due to their high viscosity and their hygroscopic nature, modifying natural gum at different temperature provides carrier which have low viscosity and high swelling capacity offers better alternative for natural carriers. Modification of natural gums also changes physical characteristics like swelling index, viscosity, water retention capacity and crystalline nature of powder into amorphous. It concludes that modified form of carrier always shows better desire properties for enhancing water solubility.

KEYWORDS: Solid dispersion, Modified natural gums, Carriers, Solubility.

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Author Biography

Amar Anantrao Shejul, Department of Pharmaceutics, Anuradha colleege of pharmacy, Sakegaon road ,Chikhali,Dist Buldana
India
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How to Cite
1.
Shejul A, Deshmane S, Biyani K. MODIFIED NATURAL CARRIER IN SOLID DISPERSION FOR ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE DRUGS. JDDT [Internet]. 14Jan.2014 [cited 27Jan.2021];4(1):111-6. Available from: http://jddtonline.info/index.php/jddt/article/view/749