SYNTHESIS, CHARACTERIZATION OF 2,4 -THIAZOLIDINEDIONE DERIVATIVES AND EVALUATION OF THEIR ANTIOXIDANT ACTIVITY
The research work was carried out to evaluate the antioxidant activity of derivatives of 2, 4-thiazolidinedione (ISS-1, ISS-2, ISS-3, ISS-4, and ISS-5). Thiazolidinedione are synthetic agonists for the transcription factor peroxisome proliferators activated receptor gamma and are therapeutically used as insulin sensitizers. 2, 4-thiazolidinedione derivatives show variety of biological activities such as antibacterial, antifungal, anti-inflammatory, antitumor, anticonvulsant, and cardiotonic besides showing promising anti- diabetic activity. 2, 4-thiozolidinedione was synthesized by condensing thiourea with chloroacetic acid in the presence of concentrated hydrochloric acid and water. A series of derivatives of 2, 4-thiazolidinedione was prepared by mannish reaction by reacting various secondary amines with formaldehyde. In these mannish reaction derivatives of 2, 4-thiazolidinedione has been used as hydrogen active compounds. The synthesized compounds were characterized by IR, 1H NMR and chromatographic method (TLC). The mannish base derivatives of 2, 4-thiazolidinedione were tested for antioxidant activity using free radical scavenging activity by DPPH (1, 1-diphenyl-2-picryl-hydrazil) assay method and ascorbic acid was used as reference standard. All the tested mannish base derivatives show antioxidant activity but compound ISS-3 and ISS-5 show promising antioxidant activity concentration at 50Âµg /ml and can be further studied with modifications.
Keywords: 2, 4-thiazolidinedione, ascorbic acid, antioxidant activity.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).