METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF IRBESARTAN IN BULK DRUG AND PHARMACEUTCAL DOSAGE

Laxmi Banjare, Jay Kumar Chandra, Prabhat Patel

Abstract


Simple, sensitive, accurate, precise and rapid ultraviolet (UV) spectrophotometric method was developed for the estimation of Irebesartan  in pure form, its formulations and stability samples. Sample recovery in both the formulations using the above method was in good agreement with their respective labeled claims, thus suggesting the validity of the method and non-interference of formulation excipients in the estimation. Detection wavelength was selected as 263 nm Linearity in response was observed in the range of 10-100 µg/ml having R2 = 0.999. ( R2= not less then  .996 ) The regeration equ. y= y=mx+c was calculated   as Y = The sandell’s sensitivity for the developed method was found to be1.6269. The values were founds to be within the official limit. The percentage purity of three different samples, 12, 14, and 16µg/ml was found to be 92.44 ,87.49, 83.47respectively. The percentage recovery results revealed that the value is 100%, which indicates that the proposed method is accurate as the results are within the official limits.

Keywords: ultraviolet (UV) spectrophotometric method, Irebesrtan ,recovery experiment ,determination of linearity


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