FLUPIRTINE: A MINI REVIEW
Pain is the oldest medical problem of human, yet it has been little understood in physiology until very recently. Persistent, unremitting pain may adversely affect the bodyâ€™s endocrine, cardiovascular, immune, neurologic and musculo-skeletal systems and require aggressive treatment of the pain as well as its complications. It can significantly interfere with a person's quality of life and general functioning. So, treatment of this sensation is a challenge for clinicians. Flupirtine is a novel, centrally acting, non-opioid and non NSAID analgesic agent, and is devoid of common adverse effects seen with NSAIDs and opioids. It was first synthesized and used in Europe although it is not yet approved by United States Food and Drug Administration (USFDA). It acts as a selective neuronal potassium channel opener and has indirect N-methyl-d-aspartate (NMDA) receptor antagonist properties. In addition to analgesic action, it has also muscle relaxant, antioxidant, neuroprotective and antiparkinsonian effects. It is presently under phase II clinical trials for fibromyalgia. Evidence of flupirtine's efficacy from clinical trials and well-established use in European countries for more than 25 years suggests that it has a unique and important place in pain management. Despite its broad spectrum action, it is among such drugs which were not popular worldwide for a long time becauseÂ they were not approved by USFDA.
Key Words: Pain, Flupirtine, Selective neuronal potassium channel openers, Neuroprotective, Antioxidant.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).