STUDY OF THE EVALUATION OF MUTAGENIC EFFECTS OF ANTIMALARIAL DRUG CHLOROQUINE IN AMES SALMONELLA ASSAY
Antimalarial drugs are frequently administered to people in topical regions of the world. It is known that commonly used antimalarial drug Chloroquine binds strongly to deoxyribonucleic acid (DNA). Â In the present study the mutagenic effects of antimalarial drug Chloroquine was evaluated in the Ames Salmonella assay .CHQ is the most commonly used antimalarial drug at present in different parts of the world. After the malaria parasite Plasmodium falciparum started to develop widespread resistance to CHQ, new potential utilizations of this cheap and widely available drug have been investigated. CHQ has been extensively used in mass drug administrationâ€™s which may have contributed to the emergence and spread of resistance. As it mildly suppresses the immune system, it is used in some autoimmune disorders, such as rheumatoid arthritis. CHQ is in clinical trials as an investigational antiretroviral in humans with HIV-1/AIDS The results of the mutagenicity assay indicate that chloroquine is a weak mutagen in Salmonella strain TA100. CHQ showed a very weak mutagenic effect in the absence of S9 mix in strain TA100. But this compound didnâ€™t show any mutagenic effect on TA98 strain both in presence or absence of S9 mix. This observation suggests that metabolic products of CHQ might not play a significant role in induction of mutation.
Keywords: Chloroquine, Ames Salmonella assay, mutagenic effect
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