formulation and evaluation of topical gel of aceclofenac
AbstractTopical gel formulations of Aceclofenac were prepared using these polymers such as Carbopolâ€934, Carbopolâ€941, HPMC, Poloxamer 407 in different concentration for the treatment of rheumatoid arthritis. The gels were evaluated for various parameters such as homogeneity, grittiness, skin irritancy, extrudability, in vitro drug release, viscosity(Brooke field viscometer), pH, drug content, stability studies. The in vitro release rate of gel was evaluated using Franz diffusion cell containing cellophane membrane with phosphate buffer pH 7.4 as the receptor medium. The release rate of the gel was found to obey Higuchi model. The percentage of drug release follow following order Poloxamer-407> HPMC> Carbopol-940>Carbopol-934. Keywords: Aceclofenac, carbopol, poloxamer hydroxyl propyl methyl cellulose, anti inflammatory activity.
Download data is not yet available.
59 Views | 579 Downloads
How to Cite
guleri, tarun. (2013). formulation and evaluation of topical gel of aceclofenac. Journal of Drug Delivery and Therapeutics, 3(6), 51-53. https://doi.org/10.22270/jddt.v3i6.682
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeÂ The Effect of Open Access).