FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL DRUG DELIVERY SYSTEM OF GLIPIZIDE

  • Chirag Patel "Rajasthan University Of Health Science"
  • Dhruv K Mangukia Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, India
  • Rajesh Asija Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, India
  • Sanjeeta Asija Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, India
  • Sandeep Kataria

Abstract

Abstract:

Context: There has been a tremendous increase in interest for transdermal drug delivery system for sustain release dosage form in chronic manageable diseased conditions like diabetes, hypertension etc to reduce the frequency of dosing. It reduces the risk of exposing the body to drug above maximum safe concentration in case of dosage form failure in comparison to oral sustained release drug delivery system.

Aims: Transdermal patches of Glipizide were formulated to achieve sustain release pattern within the therapeutic range.

Methods and Material: HPMC 5cps, HPMC 15cps, HPMC K-100M, Ethyl cellulose (EC), Eudragit RS 100 (ERS-100) and Polyvinylpyrrolidone (PVP) K30 were used as matrix forming polymer. Propylene glycol was used as penetration enhancer. Polyethylene glycol (PEG) 400 and n-dibultyl phthalate (n-DB) were used as plasticizer. Methanol and chloroform were used as solvents. Patches were prepared by solvent casting method.

Results: Patches prepared, from each batch, gave release profile for over 10 hours.

Conclusions: Prepared patches from HPMC 5 cps and ethyl cellulose exhibited good characteristics for sustained release action and other parameters evaluated.

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Author Biographies

Chirag Patel, "Rajasthan University Of Health Science"

chirag patel

i complited my B.Pharm from K.E.L. Collage of pharmacy , Bangalore.i am doing my M.Pharma from Maharishi Arvind Intitute Of Pharmacy.

Dhruv K Mangukia, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, India

Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, India

Rajesh Asija, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, India

Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, India

Sanjeeta Asija, Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, India

Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur-302020, India

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How to Cite
1.
Patel C, Mangukia D, Asija R, Asija S, Kataria S. FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL DRUG DELIVERY SYSTEM OF GLIPIZIDE. JDDT [Internet]. 19Jan.2012 [cited 27Jan.2021];2(1). Available from: http://jddtonline.info/index.php/jddt/article/view/66