COMPARISION OF LOCAL ANAESTHETIC POTENTIALS OF DRUGS HAVING MEMBRANE STABILIZING EFFECT ON INFILTRATION ANAESTHESIA IN GUINEA PIGS
Objective : To compare the local anaesthetic action of central neuron sodium channel blockers Phenytoin Sodium, Sodium Valproate and Carbamazepine with peripheral neuron sodium channel blockers Lignocaine using Infiltration anaesthesia in guinea pigs
Material and Methods: In the present study,the local anaesthetic effect of Lignocaine with concentration of 0.2%, 0.1% ,0.05% was compared with Phenytoin Sodium, Sodium Valproate and Carbamazepine in concentrations of 0.2%, 0.1% ,0.05% using different dilutions ofÂ 0.05N,0.1N,0.2N HCLÂ in guinea pig by pricking on the skin produces a squeak orÂ movementÂ indicating pain is produced.
Results : The results of our present study suggest onset of local anaesthesia with lignocaine 0.2% is significantly fast when compared with concentration of 0.1%, and 0.05% indicating it has better efficacyÂ whenÂ using for variousÂ Â local anaestheticÂ procedures. In addition onset of local anaesthesia with Phenytoin sodium concentrations of 0.2%, 0.1% ,0.05% Â is fast Â when compared with Sodium valproate concentrations of 0.2%, 0.1% ,0.05% Â andÂ Carbamazepine concentrations 0.2%, 0.1% ,0.05%.
Conclusion: Among antiepileptic drugs with local anaesthesia and Â membrane stabilizing activity Phenytoin sodium showed fast on set of action when compared with sodium valproate and Carbamazepine indicating it has better efficacy.
Keywords : Local Anaesthetics, Membrane Stabilizing, Infiltration anaesthesia.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).