DEVELOPMENT AND EVALUATION OF BILAYERED GASTRO-RETENTIVE TABLET CONTAINING METFORMINHCL SR AND PIOGLITAZONEHCL IR

  • Jigar Vyas Sigma Institute of pharmacy, At: Bakrol, Ajwa-Nimeta Road, Ta: Waghodiya, Dist: Vadodara. Pin: 390019
  • Tulsi p Upadhyay gujarat technical university
  • Harsh Vyas Sigma Institute of pharmacy, At: Bakrol, Ajwa-Nimeta Road, Ta: Waghodiya, Dist: Vadodara. Pin: 390019
  • Pankit Dhameliya Sigma Institute of pharmacy, At: Bakrol, Ajwa-Nimeta Road, Ta: Waghodiya, Dist: Vadodara. Pin: 390019
  • Nirali Thakkar Sigma Institute of pharmacy, At: Bakrol, Ajwa-Nimeta Road, Ta: Waghodiya, Dist: Vadodara. Pin: 390019

Abstract

To get advantage of novel drug delivery in treatment of diabetes mellitus is centered aim of this work.Bi-layered gastro-retentive tablet containing MetforminHCl and PioglitazoneHCl for treatment of type-II diabetes mellitus has been formulated . To make the system more effective, combination of immediate layer, PioglitazoneHCl 15mg and sustained release layer of MetforminHCl 500mg were prepared. The core tablet of MetforminHCl was prepared by using different swellable polymers like HPMC E15, HPMC K100 and carbopol by wet granulation method and evaluated for swelling index, total floating time and floating lag time. In vitro release studies were carried out with 0.1N HCl using USP dissolution apparatus 2 (paddle). Tablet thus formulated using HPMC K100M and E15 provided sustained release of Metformin HCl over a period of 10 hours. The immediate release layer of PioglitazoneHCl was prepared by using crosspovidone,a super disintegrant  by direct compression method and evaluated for disintegration time and dissolution also. Then bilayered tablet was prepared with the selected core tablet batch of MetforminHCl followed by compression coating with the selected immediate release layer of PioglitazoneHCl. The present study concluded that bilayered tablet can be a good way to treat diabetic patients with combination therapy.

Downloads

Download data is not yet available.
Statistics
96 Views | 117 Downloads
How to Cite
1.
Vyas J, Upadhyay T, Vyas H, Dhameliya P, Thakkar N. DEVELOPMENT AND EVALUATION OF BILAYERED GASTRO-RETENTIVE TABLET CONTAINING METFORMINHCL SR AND PIOGLITAZONEHCL IR. JDDT [Internet]. 14Sep.2013 [cited 18Feb.2020];3(5):58-1. Available from: http://jddtonline.info/index.php/jddt/article/view/620