DEVELOPMENT AND EVALUATION OF BILAYERED GASTRO-RETENTIVE TABLET CONTAINING METFORMINHCL SR AND PIOGLITAZONEHCL IR
AbstractTo get advantage of novel drug delivery in treatment of diabetes mellitus is centered aim of this work.Bi-layered gastro-retentive tablet containing MetforminHCl and PioglitazoneHCl for treatment of type-II diabetes mellitus has been formulated . To make the system more effective, combination of immediate layer, PioglitazoneHCl 15mg and sustained release layer of MetforminHCl 500mg were prepared. The core tablet of MetforminHCl was prepared by using different swellable polymers like HPMC E15, HPMC K100 and carbopol by wet granulation method and evaluated for swelling index, total floating time and floating lag time. In vitro release studies were carried out with 0.1N HCl using USP dissolution apparatus 2 (paddle). Tablet thus formulated using HPMC K100M and E15 provided sustained release of Metformin HCl over a period of 10 hours. The immediate release layer of PioglitazoneHCl was prepared by using crosspovidone,a super disintegrantÂ by direct compression method and evaluated for disintegration time and dissolution also. Then bilayered tablet was prepared with the selected core tablet batch of MetforminHCl followed by compression coating with the selected immediate release layer of PioglitazoneHCl. The present study concluded that bilayered tablet can be a good way to treat diabetic patients with combination therapy.
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Vyas J, Upadhyay T, Vyas H, Dhameliya P, Thakkar N. DEVELOPMENT AND EVALUATION OF BILAYERED GASTRO-RETENTIVE TABLET CONTAINING METFORMINHCL SR AND PIOGLITAZONEHCL IR. JDDT [Internet]. 14Sep.2013 [cited 31Mar.2020];3(5):58-1. Available from: http://jddtonline.info/index.php/jddt/article/view/620
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