FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF PERINDOPRIL ERBUMINE USING NATURAL SUPERDISINTEGRANT

  • Pradeep Shamgouda Patil R.C.Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule:-425405
  • Akshata K More Bhalchandra College of Pharmacy, Pune-411025.
  • Sunil Kadam Bhalchandra College of Pharmacy, Pune-411025.
  • Vishal Vishwasrao Bhalchandra College of Pharmacy, Pune-411025.
  • Yagnik Patel Bhalchandra College of Pharmacy, Pune-411025.

Abstract

Oral disintegrating tablets are emerging trend in Novel drug delivery system & received increasing demand & popularity due to ease of administration & better patient compliance .In recent years superdisintegrant have been employed to develop  effectual mouth dissolving tablet & to overcome limitation of conventional tablets .In present study attempt was made to compare to disintegrating  efficiency of natural superdisintegrats .Main aim of using oscimum basilicum as natural superdisintegrant was to achieve quick onset of action ,increases water uptake with short wetting time & decreasing disintegration time  by cost effective direct compression method. 3 preliminary batches were prepared & these are evaluated for precompression parameter like angle of repose, carr`s index & post compression parameters like wetting time, water absorption ratio,in vitro disintegration. Hardness, friability of all formulations found within limit. Best formulation F2 batch had shown good hardness, friability, disintegration time, swelling time. Present study revealed that mucilage obtained from oscimum basilicum was effective for their disintegrating property.

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Author Biography

Pradeep Shamgouda Patil, R.C.Patel Institute of Pharmaceutical Education and Research, Shirpur, Dhule:-425405
Asst. Professor in department of Pharmaceutics
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1.
Patil P, More A, Kadam S, Vishwasrao V, Patel Y. FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF PERINDOPRIL ERBUMINE USING NATURAL SUPERDISINTEGRANT. JDDT [Internet]. 14Sep.2013 [cited 18Feb.2020];3(5):44-8. Available from: http://jddtonline.info/index.php/jddt/article/view/599