PREPARATION AND EVALUATION OF SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM FOR FEXOFENADINE HYDROCHLORIDE
AbstractDevelopinga drug product with desirable bioavailability is a challenge for sparinglywater soluble drugs such as Fexofinadine hydrochloride. Objective: In the present investigation self microemulsifying drugdelivery system (SMEDDS) of Fexofenadine hydrochloride was developed forimproving solubility and dissolution rate of drug. Material Method: Solubility of Fexofenadine hydrochloride wasdetermined in various non-aqueous vehicles such as oils, surfactants, andco-surfactants. Psuedoternary phase diagrams were constructed to identify theself-micro emulsification region. Four formulations of SMEDDS were selected fromthe optimum concentration of oils, surfactant, and co-surfactants from psuedoternary diagrams. Resultsand Discussion: Selected formulations were evaluated for droplet size,in-vitro drug dissolution, drug content and solubility of drug. The optimumformulation was 20% oleic acid, 26.3% ACONON MC8 and 53.3% PEG 400. Self-microemulsification with the combination of oleic acid and ACONON MC8 was foundhigher. Conclusion: The resultsobtained from in vitro dissolutionindicated Fexofenadine hydrochloride in SMEDDS dissolved rapidly and completelyin phosphate buffer pH 6.8 which was used as dissolution medium.
Download data is not yet available.
306 Views | 550 Downloads
How to Cite
Patel A, Patel J, Patel T, Suhagia B, Patel T. PREPARATION AND EVALUATION OF SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM FOR FEXOFENADINE HYDROCHLORIDE. JDDT [Internet]. 13Jul.2013 [cited 25Sep.2022];3(4):26-2. Available from: http://jddtonline.info/index.php/jddt/article/view/576
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).