EVALUATION OF ANALGESIC ACTIVITY OF ROOTS OF PICRORHIZA KURROA

  • rupali laxman shid Student,Rajgad Dyanpeeth's College Of Pharmacy,Bhor,Pune
  • soma bhatacharya raha Proffessor,Rajgad Dyanpeeth's College Of Pharmacy,Bhor,Pune
  • Santosh laxman shid

Abstract

Methodology:-The selected drug from the authentic literature is in form of dried roots of Picrohiza kurroa belonging to family scrophulariaceae.  Analgesic  activity of root powder is extracted with alcohol for 7 days.  The extracts in these dose levels of 250 mg/kg, 500 mg/kg were tested.  The analgesic activity was studied by using the Hot plate and Acetic acid induced-writhing method in albino mice of either sex. The writhing are measured within 10 min.

Results:- The 500mg/kg drug of picrorhiza kurroa having similar effect to the standard drug pentazocin at ½ hrs.pentazocin is agonist-antagonist type of analgesic drug.in hot plate method the 500mg/ kg drug of picrorhiza kurroa is effective at the ½ hrs than the 250mg/ kg

Conclusions:-Dose effective of ethanolic extract of  picrorhiza kurroa 500 mg/kg. by Hot    plate method and Acetic acid induced writhing method.

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1.
shid rupali, raha soma, shid S. EVALUATION OF ANALGESIC ACTIVITY OF ROOTS OF PICRORHIZA KURROA. JDDT [Internet]. 13Jul.2013 [cited 25Sep.2022];3(4):99-04. Available from: http://jddtonline.info/index.php/jddt/article/view/557