A COMPARATIVE STUDY OF EFFICACY OF PEFLOXACIN VERSUS PEFLOXACIN AND ALKALINISING AGENT IN THE TREATMENT OF URINARY TRACT INFECTION

  • amit kumar ghosh R.G.Kar Medical College & Hospital
  • chanchal kumar dalai College of Medicine & JNM Hospital
  • anup kumar das R.G.Kar Medical College & Hospital

Abstract

Background-

In urinary tract infection (UTI) alkalinisation of urine is a common practice, which may change or altered the effect of some antimicrobial treatment. Pefloxacin, a well-known fluoroquinolone used for treatment of urinary tract infection is found to be effective. On this background, the study was done to evaluate the effect of pefloxacin in presence of alkalinising agent.

AIM-

To evaluate the antimicrobial effect of pefloxacin both in presence and absence of alkalinising agent.

 

SETTINGS AND DESIGN-

Prospective, interventional, randomized, assessor blind, fixed dose with two parallel treatment groups and unicentric.

 

RESULTS:

Pefloxacin was effective in 100% when used alone, but in presence of disodium hydrogen citrate, the urinary alkalinising agent solution, effectivity of pefloxacin came to 45.71%.

 

CONCLUSION

To conclude, it is said that the efficacy of pefloxacin has been reduced after alkalinisation of urine.

 

KEY WORDS- UTI, Pefloxacin, disodium hydrogen citrate

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Author Biographies

amit kumar ghosh, R.G.Kar Medical College & Hospital

Department of Pharmacology

Associate Professor

chanchal kumar dalai, College of Medicine & JNM Hospital
Department-pharmacology Rank-Assistant Professor
anup kumar das, R.G.Kar Medical College & Hospital

Department of Pharmacology

Professor

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How to Cite
1.
ghosh amit, dalai chanchal, das anup. A COMPARATIVE STUDY OF EFFICACY OF PEFLOXACIN VERSUS PEFLOXACIN AND ALKALINISING AGENT IN THE TREATMENT OF URINARY TRACT INFECTION. JDDT [Internet]. 13Jul.2013 [cited 25Jan.2021];3(4):43-6. Available from: http://jddtonline.info/index.php/jddt/article/view/539