A COMPARATIVE STUDY OF EFFICACY OF PEFLOXACIN VERSUS PEFLOXACIN AND ALKALINISING AGENT IN THE TREATMENT OF URINARY TRACT INFECTION
In urinary tract infection (UTI) alkalinisation of urine is a common practice, which may change or altered the effect of some antimicrobial treatment. Pefloxacin, a well-known fluoroquinolone used for treatment of urinary tract infection is found to be effective. On this background, the study was done to evaluate the effect of pefloxacin in presence of alkalinising agent.
To evaluate the antimicrobial effect of pefloxacin both in presence and absence of alkalinising agent.
SETTINGS AND DESIGN-
Prospective, interventional, randomized, assessor blind, fixed dose with two parallel treatment groups and unicentric.
Pefloxacin was effective in 100% when used alone, but in presence of disodium hydrogen citrate, the urinary alkalinising agent solution, effectivity of pefloxacin came to 45.71%.
To conclude, it is said that the efficacy of pefloxacin has been reduced after alkalinisation of urine.
KEY WORDS- UTI, Pefloxacin, disodium hydrogen citrate
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).