formulation and evaluation of solid dispersions of nabumetone

  • hyma ponnaganti

Abstract

Solid  dispersions  are  an  effective  method  of  increasing  the  solubility  and bioavailability of  poorly  soluble  drugs.  In  the  present  study  it  is  aimed  at  to  enhance  solubility  of Nabumetone  a poorly  soluble  anti-inflammatory  drug  by  solid  dispersion  technique  by employing  solvent  evaporation  technique  using  PEG  4000  And PEG 6000 as  carriers.  The  formulations  were  prepared  in  ratios  of  1:1, 1:2 , 1:3, 1:4  and  characterized  by  FTIR,  XRD,  and  dissolution  studies. The  prepared  solid  dispersions  showed  excellent  improvement  of drug  solubility  due  to  mean  drug  particle  size  reduction which  lead  to  increase  drug  dissolution  and  bioavailability

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ponnaganti hyma. formulation and evaluation of solid dispersions of nabumetone. JDDT [Internet]. 13Jul.2013 [cited 25Feb.2020];3(4):15-9. Available from: http://jddtonline.info/index.php/jddt/article/view/531