formulation and evaluation of solid dispersions of nabumetone
AbstractSolidÂ dispersionsÂ areÂ anÂ effectiveÂ methodÂ ofÂ increasingÂ theÂ solubilityÂ and bioavailability ofÂ poorlyÂ solubleÂ drugs.Â InÂ theÂ presentÂ studyÂ itÂ isÂ aimedÂ atÂ toÂ enhanceÂ solubilityÂ of NabumetoneÂ a poorlyÂ solubleÂ anti-inflammatoryÂ drugÂ byÂ solidÂ dispersionÂ techniqueÂ by employingÂ solventÂ evaporationÂ techniqueÂ usingÂ PEGÂ 4000Â And PEG 6000 asÂ carriers.Â TheÂ formulationsÂ wereÂ preparedÂ inÂ ratiosÂ ofÂ 1:1, 1:2 , 1:3, 1:4Â andÂ characterized Â byÂ FTIR,Â XRD,Â andÂ dissolutionÂ studies. TheÂ preparedÂ solidÂ dispersionsÂ showedÂ excellentÂ improvementÂ of drugÂ solubilityÂ dueÂ toÂ meanÂ drugÂ particleÂ sizeÂ reduction whichÂ leadÂ toÂ increaseÂ drugÂ dissolutionÂ andÂ bioavailability
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ponnaganti hyma. formulation and evaluation of solid dispersions of nabumetone. JDDT [Internet]. 13Jul.2013 [cited 25Feb.2020];3(4):15-9. Available from: http://jddtonline.info/index.php/jddt/article/view/531
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