A Review of Plants with Remarkable Hepatoprotective Activity
Abstract
Liver being vulnerable to exogenous substances makes disease associated with it a matter of worldwide concern. Several research thus focus on hepatoprotection .Preventive and therapeutic activity of plants as a hepatoprotective agent is a topic of interest for researchers. Hepatotoxic agents like carbon tetrachloride, paracetamol, isoniazide etc. increase the serum biomarkers of liver where ALT is more specific than AST in detecting liver injury. Drug-induced liver injury (DILI) wherein more than 900 drugs have been implicated in causing liver injury. Plant phenolics include simple phenols, phenolic acids, coumarins, lignans, flavonoids, diaryl-alkanoids, stilbenoids, proanthocyanins, tannins, and anthocyanins some alkaloids. The greater the content of alkaloids, flavonoids, and saponins in an extract, the higher the hepatoprotective activity possessed by the extract. This paper reviews some plants documented between the periods of 2011-2021 with remarkable heptoprotective activity and discusses the various hepatotoxic agents used, its mechanism and hepatoprotective agents present in the specific plant.
Keywords: Hepatoprotective plants, flavonoids, saponin, alkaloids,hepatotoxicity, drug induced liver injury, hepatotoxic agents
Keywords:
Hepatoprotective plants, flavonoids, saponin, alkaloids, hepatotoxicity, drug induced liver injury, hepatotoxic agents
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References
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5. Chaudhary S, Gupta RK, Gupta MK, Verma HC, Kumar H, Swain SR, et al. Hepatoprotective response of Cordia sebestena L. fruit against simvastatin induced hepatotoxicity. Journal of Pharmacy & Pharmacognosy Research2020; 8 (4):327-335 http://jppres.com/jppres
6. Marianne M, Harahap U, Hasibuan PAZ, Thampati CM, Harefa HS. Hepatoprotective activity of the ethanol extract of Curcuma heyneana rhizome on isoniazid and rifampin-induced liver injury rats. Journal of Herbmed Pharmacology.2020 Jul 1; 9(4):333-8. https://doi.org/10.34172/jhp.2020.42 http://herbmedpharmacol.com/Article/jhp-13392
7. Nerdy N, Ritarwan K. Hepatoprotective Activity and Nephroprotective Activity of Peel Extract from Three Varieties of the Passion Fruit (Passiflora Sp.) in the Albino Rat. Open Access Maced J Med Sci. 2019 Feb 27; 7(4):536-42. https://doi.org/10.3889/oamjms.2019.153 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420947/
8. Alasyam N, Pokala N, John P. Evaluation of hepatoprotective activity of aqueous extract of Phyllanthus fraternus in Wistar rats. National Journal of Physiology Pharmacy and Pharmacology. 2019; 9(3):1. https://doi.org/10.5455/njppp.2019.9.1237012012019 http://www.njppp.com/index.php?mno=22056
9. Singh M P, Valte V,Raleng I,RK SL.Hepatoprotective activity of ethanol extract of Pavetta Indica Linn leaves.Indian Journal of Pharmacy and Pharmacology.2020 Dec 28; 5(1):37-9. https://doi.org/10.18231/2393-9087.2018.0009 http://oaji.net/articles/2017/1495-1525332796.pdf
10. Rajendiran D,Raghavan S,Kandaswamy S,and Gunasekaran K. Hepatoprotective activity of ethanol extract of Mimosa pudica leaves in type 2 diabetic rats. The Pharma Innovation Journal 2018; 7(12):223-226 https://www.thepharmajournal.com/archives/?year=2018&vol=7&issue=12&ArticleId=2824
11. Patil A.A.S.S,Hoskeri H.J, P Rajeev, Kulkarni B,Kamble G.R,Hiremath G.B, Kalebar V, Hiremath S.V.Hepatoprotective activity of methanolic shoot extract of Bambusa bambos against carbon tetrachloride induce acute liver toxicity in Wistar rats. J App Biol Biotech. 2018; 37-40. https://doi.org/10.7324/JABB.2018.60407 https://jabonline.in/admin/php/uploads/284_pdf.pdf
12. Sadeghi H, Hosseinzadeh S, Touri MA, Barmak MJ. Hepatoprotective effect of Rosa canina fruit extract against carbon tetrachloride induced hepatotoxicity in rat.Avicenna J Phyto Med.2016; 6(2):8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877970/
13. Mundugaru R, Chakkravarthy M, Basavaiah R. Hepatoprotective activity of fruit extract garcinia pedunculata. Bangladesh J Pharmacol. 2014 Oct 1; 9(4):483-7. https://doi.org/10.3329/bjp.v9i4.19910 https://www.researchgate.net/publication/282162075_Hepatoprotective_activity_of_fruit_extract_of_Garcinia_pedunculata
14. Okoli J TN,Agbo MO, and Ukekwe FI.Antioxidant and Hepatoprotective Activity of Fruit Extracts of Tetrapleura tetraptera (Schum & Thonn) Taubert. Jordan Journal of Biological Sciences. 2014 December; 7(4):1995-6673 https://doi.org/10.12816/0008247 https://jjbs.hu.edu.jo/files/v7n4/Paper%20Number%203m.pdf
15. Karami M, Saeidnia S, Nosrati A. Study of the Hepatoprotective Activity of Methanolic Extract of Feijoa sellowiana Fruits Against MDMA using the Isolated Rat Liver Perfusion System.Iranian Journal of Pharmaceutical Research. 2013; 12 (1):85-91 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813203/
16. Pachpute AP,Deshmukh TA. Antioxidant and hepatoprotective activity of an ethanol extract of piper cubeba fruits.International Journal Of Research And Development In Pharmacy And Life Sciences. 2013 February - March; 2(2):321-329 http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.392.2666&rep=rep1&type=pdf
17. Dar AI, Saxena RC, Bansal SK. Assessment of hepatoprotective activity of fruit pulp of Feronia limonia (Linn.) against paracetamol induced hepatotoxicity in albino rats. Journal of Natural Products.2012; 2 (2):226-233 https://www.scholarsresearchlibrary.com/abstract/assessment-of-hepatoprotective-activity-of-fruit-pulp-of-feronia-limoniarnlinn-against-paracetamol-induced-hepatotoxicit-5201.html
18. Gupta RK, Hussain T, Panigrahi G, Das A, Singh GN, Sweety K, et al. Hepatoprotective effect of Solanum xanthocarpum fruit extract against CCl4 induced acute liver toxicity in experimental animals. Asian Pacific Journal of Tropical Medicine. 2011 Dec; 4(12):964-8. https://doi.org/10.1016/S1995-7645(11)60227-7 https://pubmed.ncbi.nlm.nih.gov/22118032/
19. Pandit A,Sachdeva T and Bafna P. Drug-Induced Hepatotoxicity: A Review. J App Pharm Sci [Internet]. 2012 May 28 [cited 2021 Nov 8]; Available from: http://www.japsonline.com/vol-2-issue-5/233-243.pdf
20. Fisher K, Vuppalanchi R, Saxena R. Drug-Induced Liver Injury. Arch Pathol Lab Med. 2015; 139:12. https://doi.org/10.5858/arpa.2014-0214-RA https://pubmed.ncbi.nlm.nih.gov/26125428/
21. David S, Hamilton JP. Drug-induced Liver Injury. NIH Public Access.2010 January 1; 6:73-80. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160634/
22. Rotundo L, Pyrsopoulos N. Liver injury induced by paracetamol and challenges associated with intentional and unintentional use. WJH. 2020 Apr 27; 12(4):125-36. https://doi.org/10.4254/wjh.v12.i4.125 https://pubmed.ncbi.nlm.nih.gov/32685105/
23. Björnsson ES. Hepatotoxicity of statins and other lipid-lowering agents. Liver Int.2017 Feb; 37(2):173-8. https://doi.org/10.1111/liv.13308 https://pubmed.ncbi.nlm.nih.gov/27860156/
24. Karahalil B, Hare E, Koç G, Uslu İ, Şentürk K, Özkan Y. Hepatotoxicity associated with statins. Archives of Industrial Hygiene and Toxicology. 2017 Dec 20; 68(4):254-60. https://doi.org/10.1515/aiht-2017-68-2994 https://pubmed.ncbi.nlm.nih.gov/29337684/
25. Singh R, Chahal KK. Cichorium intybus L: A review on phytochemistry and pharmacology. International Journal of Chemical Studies, ; 6(3):1272-1280 https://www.researchgate.net/profile/Ravinder-Singh-56/publication/332013279_Cichorium_intybus_L_A_review_on_phytochemistry_and_pharmacology/links/60f01b420859317dbde35df8/Cichorium-intybus-L-A-review-on-phytochemistry-and-pharmacology.pdf
26. Anju, Javed G, Javaid R, Ahmed F. Kasni (Cichorium intybus): A Unani Hepatoprotective Drug. J Drug Delivery Ther. 2020 Jul 15; 10(4):238-41. https://doi.org/10.22270/jddt.v10i4.4162 http://jddtonline.info/index.php/jddt/article/view/4162
27. Richa U and Nath T.K. Phyllanthus fraternus a potent natural antioxidant as pharmaceutical supplement. Research Journal of Biotechnology. 2018 September; 13(9)
https://www.researchgate.net/publication/327513712_Phyllanthus_fraternus_a_potent_natural_antioxidant_as_pharmaceutical_supplement
28. Seena H, Kannappan N, Manojkumar P. Evaluation of Phytochemical,anti-oxidant and hepatoprotective activities of methanolic extract of Pavetta Indica. Asian Journal of Research in Chemistry and Pharmaceutical Sciences. 2019; 7(2):379-387.
29. Saague PWK, Moukette Moukette B, Njimou JR, Biapa PCN, Nzufo Tankeu F, Moor VJA, et al. Phenolic Compounds from Water-Ethanol Extracts of Tetrapleura tetraptera Produced in Cameroon, as Potential Protectors against In Vivo CC l 4 -Induced Liver Injuries. The Scientific World Journal. 2019 Mar 3; 2019:1-10. https://doi.org/10.1155/2019/5236851 https://www.hindawi.com/journals/tswj/2019/5236851/
30. AlSaid M, Mothana R, Raish M, Al-Sohaibani M, Al-Yahya M, Ahmad A, et al. Evaluation of the Effectiveness of Piper cubeba Extract in the Amelioration of CCl 4 -Induced Liver Injuries and Oxidative Damage in the Rodent Model. BioMed Research International. 2015; 2015:1-11. https://doi.org/10.1155/2015/359358 https://www.hindawi.com/journals/bmri/2015/359358/
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Meshack S, Gupta S. A Review of Plants with Remarkable Hepatoprotective Activity. JDDT [Internet]. 15Jan.2022 [cited 17Apr.2024];12(1):194-02. Available from: https://jddtonline.info/index.php/jddt/article/view/5283
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