Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil

  • S. Ramya PG Department of Zoology, Yadava College (Men), Thiruppalai - 625014, Madurai, TamilNadu, India
  • T. Loganathan Department of Plant Biology & Plant Biotechnology, LN Government College (A), Ponneri, TN, India
  • M. Chandran Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632 115, TamilNadu, India
  • R. Priyanka Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632 115, TamilNadu, India
  • K. Kavipriya Department of Zoology, Arignar Anna Government Arts College (W), Walajapet-632 513, TN, India
  • G. Grace Lydial Pushpalatha PG Department of Botany, Sri Meenakshi Government Arts College, Madurai-625002, TN, India
  • Devaraj Aruna Rajendra Herbal Research Training Centre, Periyakulam Theni, TamilNadu, India
  • L. Ramanathan Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India
  • R. Jayakumararaj Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India
  • Vikrant Saluja Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, India

Abstract

Seeds of cumin (Cuminum cyminum L.) are widely used as a spice for their distinctive aroma. C. cyminum have been used in traditional medicine to treat a variety of diseases. Literature presents ample evidence for biomedical activities of cumin which is attributed to its bioactive secondary metabolites - terpenes, phenols, and flavonoids. Besides, health effects of cumin seeds have been experimentally validated through phytochemical analysis depicting the presence of a wide array of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinone, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Pharmacological studies indicate that BASMs in seeds of C. cyminum exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. In the present study phytochemical screening, GCMS, FTIR profile of bioactive natural products from C. cyminum has been envisaged. Phytochemical screening revealed the presence of alkaloids, anthraquinones, carbohydrates, coumarins, flavonoids, glycosides, proteins, quinones, saponins, steroids, tannins and terpenoids. GC-MS analysis revealed the presence of 21 compounds, of which Cuminaldehyde was prominent.  FTIR analysis showed the presence of a strong peak value for 15 compounds and medium peak value for 6 compounds. Many of the compounds in the list could be ADMET bioprospected for biomedical applications as natural drug leads. 


Keywords: Cuminum cyminum; Cuminaldehyde; Bioactive Natural Products; GCMS; FTIR

Keywords: Cuminum cyminum, Cuminaldehyde, Bioactive Natural Products, GCMS, FTIR

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Author Biographies

S. Ramya, PG Department of Zoology, Yadava College (Men), Thiruppalai - 625014, Madurai, TamilNadu, India

PG Department of Zoology, Yadava College (Men), Thiruppalai - 625014, Madurai, TamilNadu, India

T. Loganathan, Department of Plant Biology & Plant Biotechnology, LN Government College (A), Ponneri, TN, India

Department of Plant Biology & Plant Biotechnology, LN Government College (A), Ponneri, TN, India

M. Chandran, Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632 115, TamilNadu, India

Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632 115, TamilNadu, India

R. Priyanka, Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632 115, TamilNadu, India

Department of Zoology, Thiruvalluvar University, Serkadu, Vellore-632 115, TamilNadu, India

K. Kavipriya, Department of Zoology, Arignar Anna Government Arts College (W), Walajapet-632 513, TN, India

Department of Zoology, Arignar Anna Government Arts College (W), Walajapet-632 513, TN, India

G. Grace Lydial Pushpalatha, PG Department of Botany, Sri Meenakshi Government Arts College, Madurai-625002, TN, India

PG Department of Botany, Sri Meenakshi Government Arts College, Madurai-625002, TN, India

Devaraj Aruna, Rajendra Herbal Research Training Centre, Periyakulam Theni, TamilNadu, India

Rajendra Herbal Research Training Centre, Periyakulam Theni, TamilNadu, India

L. Ramanathan, Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India

Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India

R. Jayakumararaj, Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India

Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India

Vikrant Saluja, Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, India

Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, India

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Ramya S, Loganathan T, Chandran M, Priyanka R, Kavipriya K, Grace Lydial Pushpalatha G, Aruna D, Ramanathan L, Jayakumararaj R, Saluja V. Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil. JDDT [Internet]. 15Apr.2022 [cited 2Jul.2022];12(2-S):110-8. Available from: http://jddtonline.info/index.php/jddt/article/view/5280

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