EFFECT OF INTERACTION BETWEEN METFORMIN AND GLIMIPERIDE ON GLYCOSYLATED HAEMOGLOBIN AND LIPID PROFILE IN STRESS INDUCED TYPE 2 DM
The aim of the present study is to evalutae the effect of metformin in combination with Glimepiride and in patient with type 2 Diabetes Mellitus.The research is carried out to Â study the effect of metformin when it is given in combination on glycaemic control in patient with type 2 Diabetes Mellitus. Patients with Glycosylated Hemoglobin more than 6.5% were included in the study. 30 animal in five group were randomly assigned for treatment based on metformin and glimepiride in a dose of 200 mg/kg and 17.5 mg/kg for 21 weeks. The comparisons were conducted between these five groups for HbA1C, FPG, PPG and lipid profile. On week 21, the significant reductions in HbA1c were found in drug treated groups but the patients treated with metformin and glimepiride resulted in significantly greater reductions in HbA1C Â . Also the greater significant reductions were observed in case of FPG, total cholesterol, serum triglyceride and LDL cholesterol in patient with metformin and glimepiride treated group.
ÂKey word-Metformin,glimiperide,Diabetes,hypoglycemic agent,safety
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).