In-silico Absorption, Distribution, Metabolism, Elimination and Toxicity profile of Isopulegol from Rosmarinus officinalis

  • R.V. Kalaimathi PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India
  • A. Jeevalatha Department of Zoology, GTN College, Dindigul, TamilNadu, India
  • Afroze Naveed Basha PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India
  • C. Kandeepan PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India
  • S. Ramya Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India
  • T. Loganathan Department of Plant Biology and Plant Biotechnology, LN Government College (Autonomous), Ponneri - 601204, TN, India
  • R. Jayakumararaj Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India

Abstract

Plant Based Natural Products (PBNPs) have contributed to the development of many drugs for diverse indications. Worldwide interest in use of plants based natural products (PBNPs) has been growing, and its beneficial effects being rediscovered for the development of new drugs. Literature survey on indigenous traditional knowledge bestows ethnopharmacological potentials of PBNPs, which has inspired research in drug discovery; further it provides a baseline for the development of novel drug leads against selected pharmacological targets. Studies report that rosemary essential oil (ROEO) extracts have hepatoprotective, antifungal, insecticide, antioxidant and antibacterial properties. However, their application is limited because of their odor, color and taste. Owing to the widespread applications of phyto-compounds in ROEO - GCMS was performed. GCMS analysis detected 22 compounds of which 6 compounds were in abundant. In the present study, isopulegol - a Prenol Lipid (Monoterpenoid) from Rosmarinus officinalis has been ADMET characterized from biomedical application point of view.


Keywords: Rosmarinus officinalis; Rosemary officinalis Essential Oils (ROEO); Pharmacological Activity; ADMET; GCMS;

Keywords: Rosmarinus officinalis, Rosemary officinalis Essential Oils (ROEO), Pharmacological Activity, ADMET, GCMS

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Author Biographies

R.V. Kalaimathi, PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India

PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India

A. Jeevalatha, Department of Zoology, GTN College, Dindigul, TamilNadu, India

Department of Zoology, GTN College, Dindigul, TamilNadu, India

Afroze Naveed Basha, PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India

PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India

C. Kandeepan, PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India

PG & Research Department of Zoology, Arulmigu Palaniandavar College of Arts & Culture, Palani – 624601, TamilNadu, India

S. Ramya, Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India

Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India

T. Loganathan, Department of Plant Biology and Plant Biotechnology, LN Government College (Autonomous), Ponneri - 601204, TN, India

Department of Plant Biology and Plant Biotechnology, LN Government College (Autonomous), Ponneri - 601204, TN, India

R. Jayakumararaj, Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India

Department of Botany, Government Arts College, Melur – 625106, Madurai, TamilNadu, India

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Kalaimathi R, Jeevalatha A, Basha A, Kandeepan C, Ramya S, Loganathan T, Jayakumararaj R. In-silico Absorption, Distribution, Metabolism, Elimination and Toxicity profile of Isopulegol from Rosmarinus officinalis. JDDT [Internet]. 15Jan.2022 [cited 19May2022];12(1):102-8. Available from: http://jddtonline.info/index.php/jddt/article/view/5188

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