Pharmacological evaluation for Anti-Anxiety and CNS depressant activity of hydro-alcoholic leaves extract of Pongamia pinnata
Abstract
The aim of this study was to assess the anti-anxiety and CNS depressant properties of hydro-alcoholic extract of Pongamia pinnata leaves (HALEPP). Standard methods were used to screen the HALEPP's phytochemicals, which showed that the extract contains Flavones, alkaloids, glycosides, proteins and amino acids, gum and mucilage as well as flavonoids, saponins, and steroid hormones. Even at the dose level of 1000 mg/kg body weight, the HALEPP showed no signs of toxicity or mortality in the acute toxicity report. The anti-anxiety behaviour of was studied using light and dark model methods in rats. The CNS depressant action was studied using the extract and actophotometer (Rolex) in rats. The research group (HALEPP 200 gm/kg treated) animals displayed strong anti-anxiety and CNS depressant behaviour similar to the control group (diazepam treated) animals in the current study. The study's findings suggest that the hydro-alcoholic Pongamia pinnata leaf extract has strong anti-anxiety and CNS depressant properties.
Keywords: Pongamia pinnata, Anti-Anxiety & CNS depressant
Keywords:
Pongamia pinnata, Anti-Anxiety, CNS depressant
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References
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2. Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology. 6th ed. Philadelphia: Churchill Livingstone; 2007.
3. Li L, Li X, Shi C, Deng Z, Fu H, Proksch P. Five flavonoids from the stems of a mangrove plant, Pongamiapinnata. Phytochem. 2006; 67:1347-52. https://doi.org/10.1016/j.phytochem.2006.05.016
4. Shameel S, Usmanghani K, Ali MS. Chemical constituents from seeds of Pongamia pinnata (L.) Pierre. Pak J Pharm Sci. 1996; 9: 11-20.
5. Tanaka T, Iinuma M, Yuki K. Flavonoids in root bark of Pongamia pinnata. Phytochem. 1992; 31:993-8. https://doi.org/10.1016/0031-9422(92)80055-J
6. Reddy S, Reddy C, Murthy KN, Raju VS. Traditional medicinal plants in Seshachalam hills, Andhra Pradesh, India. J of Med plants Res. 2009; 3(5):408-12.
7. Kirtikar KR, Basu BD. Indian Medicinal plants. Vol. I, 2nd ed. Dehradun: International Book Distributors; 1998. p. 588-596.
8. Srinivasan K, Muruganandan S, Lal J. Evaluation of anti-inflammatory Research Journal of Pharmacy and Life Sciences: Volume 1, Issue 3; September - December, 2020: Page 98 - 108 107 activity of Pongamia pinnata leaves in rats. J Ethnopharmacol. 2001; 78:151- 7. https://doi.org/10.1016/S0378-8741(01)00333-6
9. Simonsen HT, Nordskjold JB, Smitt UW. In vitro screening of Indian Medicinal Plants for antiplasmodial activity. J Ethnopharmacol. 2001; 74:195-204. https://doi.org/10.1016/S0378-8741(00)00369-X
10. Essa MM, Subramanian P. Pongamia pinnata modulates oxidant and antioxidant imbalance in ammonium chloride induced hyper ammonem. FundamlClinPharmacol. 2006; 20:299-303. https://doi.org/10.1111/j.1472-8206.2006.00410.x
11. Chopade VV, Tankar AN, Pande VV, Tekade AR, Gowekar NM, Bhandari SR, Khandake SN. Pongamiapinnata: Phytochemical constituents, traditional uses and pharmacological properties: A review. 2008; 2(2):72- 75. https://doi.org/10.4103/0973-8258.41173
12. Brijesh S, Daswani PG, Tetali P. Studies on Pongamia pinnat (L.) Pierre leaves: Understanding the mechanism(s) of action in infectious diarrhea. J Zhejiang Univ Sci. 2006; 7:665-74. https://doi.org/10.1631/jzus.2006.B0665
13. Prabha T, Dora M, Priyambada S. Evaluation of Pongamia pinnata root Extract on gastric ulcers and mucosal offensive and defensive factors in rats. Indian J Exp Biol. 2003; 41:304-10.
14. Punitha R, Manoharan S. Antihyperglycemic and antilipid peroxidative effects of Pongamia pinnata (linn.) Pierre flowers in alloxan induced diabetic. J EthonPharmacol. 2006; 105: 39-46. https://doi.org/10.1016/j.jep.2005.09.037
15. Panigrahi G, Panda C, Patra A. Extract of Sesbaniagrandiflora ameliorates hyperglycemia in high fat diet-streptozotocin induced experimental diabetes mellitus. Scientifica. 2016; 1-10. https://doi.org/10.1155/2016/4083568
16. Kokate CK. Practical Pharmacognosy, 4 th ed. NewDelhi: VallabhPrakashan; 1994. p. 107-111. 11.
17. Khandelwal KR. Practical Pharmacognosy Techniques and Experiments, 11th ed. Pune: NiraliPrakashan; 2000. p. 149-156.
18. Ghosh MN. Fundamentals of Experimental Pharmacology. 3rd ed. Kolkata: Hilton & Company; 2005. p. 175-179, 192-197.
19. Panigrahi G, Patra A. Experimental Pharmacology- I, II and III (Bridges the Gap Between Animal Models and Computer Simulation Models). 1st ed. Pune: Nirali Prakashan; 2019.
20. Vogel HG. Drug discovery and evaluation: Pharmacological Assays. Vol II, 3rd ed. New York: SpringerVerlag Berlin Heidelberg; 2008. p. 1103-106. https://doi.org/10.1007/978-3-540-70995-4
21. Rai D, Bhatia G, Patil G, Pal R, Singh S and Singh HK. Adaptogenic effect of Bacopa monniera (Bramhi). PharmacolBiochemBehav. 2003; 75:823-30. https://doi.org/10.1016/S0091-3057(03)00156-4
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Panda J, Samantaray B, Pattnaik G. Pharmacological evaluation for Anti-Anxiety and CNS depressant activity of hydro-alcoholic leaves extract of Pongamia pinnata. JDDT [Internet]. 15Aug.2021 [cited 19Apr.2024];11(4-S):22-5. Available from: https://jddtonline.info/index.php/jddt/article/view/4962
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