DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION DICLOXACILLIN AND CEFDOXIME PROXETIL IN TABLET DOSAGE FORM

  • Drupad Rajnikant Acharya Centre for Health Science,Ganpat University, Kherva, Mehsana,Gujarat.
  • Dipti B Patel Centre for Health Science,Ganpat University, Kherva, Mehsana,Gujarat.
  • Vikram V Patel

Abstract

The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of dicloxacillin and cefdoxime proxetil in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra was obtained in methanol and the determinations were made at 233.8 nm (ZCP of cefdoxime proxetil) for dicloxacillin  and 321 nm (ZCP of dicloxacillin) for cefdoxime proxetil. The linearity was obtained in the concentration range of 10-80 μg/ml for dicloxacillin and 4-32 μg/ml for cefdoxime proxetil. The mean recovery was 100.70 ± 0.38 and 99.90 ± 0.36 for dicloxacillin and cefdoxime proxetil, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of dicloxacillin and cefdoxime proxetil in pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.

Downloads

Download data is not yet available.

Author Biographies

Drupad Rajnikant Acharya, Centre for Health Science,Ganpat University, Kherva, Mehsana,Gujarat.
Pharmaceutical Analysis.
Dipti B Patel, Centre for Health Science,Ganpat University, Kherva, Mehsana,Gujarat.
Centre  for Health Science,Ganpat University, Kherva, Mehsana,Gujarat.
Statistics
137 Views | 170 Downloads
How to Cite
1.
Acharya D, Patel D, Patel V. DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION DICLOXACILLIN AND CEFDOXIME PROXETIL IN TABLET DOSAGE FORM. JDDT [Internet]. 19Jan.2012 [cited 27Jan.2021];2(1). Available from: http://jddtonline.info/index.php/jddt/article/view/49