CARDIOVASCULAR SAFETY PROFILE OF PIOGLITAZONE ALONG WITH VITAMIN E

  • Md. Akram Minhaj IEC College of Pharmacy, Greter Noida, U.P India
  • Md. Ikram IEC College of Pharmacy, Greter Noida, U.P India
  • Md Waris Jamia Hamdard, New Delhi

Abstract

The increase incidence of obesity. stress and aging in genetically predisposed population has lead to an increase in the incidence of type 2 diabetes mellitus. This led to the development of new drugs such as thiazolidinediones (TZDs) which is a agonist of Peroxisome Proliferator-Activated Receptor (PPARgamma).Pioglitazone is a TZD  have recently been identified for its severe cardiovasculara complication. Pioglitazone is oral hypoglycemic agent  which has been shown to be effective  by lowering insulin resistance.Due to its cardiovasculaqr risk factor it is combined with adjunct vitamin E,an antioxidant  in the  present study. The safety and efficacy of pioglitazone are increased several fold along with  vitamin E.

Keywords: Vitamin E,Pioglitazone, PPARγ, diabetes

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1.
Minhaj M, Ikram M, Waris M. CARDIOVASCULAR SAFETY PROFILE OF PIOGLITAZONE ALONG WITH VITAMIN E. JDDT [Internet]. 13May2013 [cited 4Dec.2021];3(3):76-0. Available from: http://jddtonline.info/index.php/jddt/article/view/483