A Review of the Pharmacological Characteristics of Vanillic Acid

  • Ashwini Ingole STUDGawande College of Pharmacy, Sakharkherda (MH), IndiaENT
  • Megha P Kadam Gawande College of Pharmacy, Sakharkherda (MH), India
  • Aishwarya P. Dalu Gawande College of Pharmacy, Sakharkherda (MH), India
  • Shital M Kute Gawande College of Pharmacy, Sakharkherda (MH), India
  • Piyusha R Mange Gawande College of Pharmacy, Sakharkherda (MH), India
  • Vaishali D Theng Gawande College of Pharmacy, Sakharkherda (MH), India
  • Om R Lahane Gawande College of Pharmacy, Sakharkherda (MH), India
  • Aniket P Nikas Gawande College of Pharmacy, Sakharkherda (MH), India
  • Yash V Kawal Gawande College of Pharmacy, Sakharkherda (MH), India
  • Shatrughna U. Nagrik Gawande College of Pharmacy, Sakharkherda (MH), India
  • Prashant A. Patil Gawande College of Pharmacy, Sakharkherda (MH), India

Abstract

A dihydroxybenzoic acid analog used as a flavoring agent is vanillic acid (4hydroxy-3-methoxybenzoic acid). It's a form of vanillin that has been oxidized. It's also a step in the process of making vanillin from Ferulic Acid. Vanillic acid has seen a lot of press because of its many uses in the cosmetics, fruit, flavorings, cigarettes,alcohols, drinks, and polymer sectors. It's said to have effective antioxidant, anti-inflammatory, and neuroprotective properties. The pharmacological impact on oxidative stress-induced neuro-degeneration, on the other hand, have not been thoroughly examined. The pharmacological properties of vanillic Acid lead to its possible use in the treatment of various diseases.


Keywords: Vanillic acid, Pharmacological Potential, wound healing, Antioxidants

Keywords: Vanillic acid, Pharmacological Potential, wound healing, Antioxidants

Downloads

Download data is not yet available.

Author Biographies

Ashwini Ingole, STUDGawande College of Pharmacy, Sakharkherda (MH), IndiaENT

Gawande College of Pharmacy, Sakharkherda (MH), India

Megha P Kadam, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

Aishwarya P. Dalu, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

Shital M Kute, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

Piyusha R Mange, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

Vaishali D Theng, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

Om R Lahane, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

Aniket P Nikas, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

Yash V Kawal, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

Shatrughna U. Nagrik, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

Prashant A. Patil, Gawande College of Pharmacy, Sakharkherda (MH), India

Gawande College of Pharmacy, Sakharkherda (MH), India

References

1] Dandekar P, Wasewar KL. Experimental investigation on extractive separation of vanillic acid. Chemical Data Collections. 2020 Dec 1; 30:100564.
2] Wang J, Fung DY. Alkaline-fermented foods: a review with emphasis on pidan fermentation. Critical Reviews in Microbiology. 1996 Jan 1; 22(2):101-38.
3] Ignat I, Volf I, Popa VI. A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables. Food chemistry. 2011 Jun 15; 126(4):1821-35.
4] Antony FM, Wasewar KL. Reactive separation of protocatechuic acid using tri-n-octyl amine and di-(2-ethylhexyl) phosphoric acid in methyl isobutyl ketone. Separation and Purification Technology. 2018 Dec 22; 207:99-107.
5] Prince PS, Rajakumar S, Dhanasekar K. Protective effects of vanillic acid on electrocardiogram, lipid peroxidation, antioxidants, proinflammatory markers and histopathology in isoproterenol induced cardiotoxic rats. European journal of pharmacology. 2011 Oct 1; 668(1-2):233-40.
6] Onofrejová L, Vašíčková J, Klejdus B, Stratil P, Mišurcová L, Kráčmar S, Kopecký J, Vacek J. Bioactive phenols in algae: The application of pressurized-liquid and solid-phase extraction techniques. Journal of pharmaceutical and biomedical analysis. 2010 Jan 20; 51(2):464-70.
7] Siraj MA, Howlader MS, Rahaman MS, Shilpi JA, Seidel V. Antinociceptive and sedative activity of Vernonia patula and predictive interactions of its phenolic compounds with the cannabinoid type 1 receptor. Phytotherapy Research. 2021 Feb; 35(2):1069-79.
8] Rahman M, Khatun A, Nesa M, Hossain H, Jahan IA. Bioactive polyphenols from the methanol extract of Cnicus arvensis (L.) Roth demonstrated antinociceptive and central nervous system depressant activities in mice. Evidence-Based Complementary and Alternative Medicine. 2015 Jan 1; 2015.
9] Guimarães R, Barros L, Dueñas M, Carvalho AM, Queiroz MJ, Santos-Buelga C, Ferreira IC. Characterisation of phenolic compounds in wild fruits from Northeastern Portugal. Food Chemistry. 2013 Dec 15; 141(4):3721-30.
10] Khatun A, Rahman M, Rahman M, Hossain H, Jahan IA, Nesa M. Antioxidant, antinociceptive and CNS activities of Viscum orientale and high sensitive quantification of bioactive polyphenols by UPLC. Frontiers in pharmacology. 2016 Jun 29; 7:176.
11] Swiss Academy of Medical Sciences, Swiss Academy of Sciences. Ethical principles and guidelines for experiments on animals. Experientia. 1993 Jan; 49:1-3.
12] Wang YS, Shen CY, Jiang JG. Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery. Pharmacological research. 2019 Dec 1; 150:104520.
13] Guo F, Tang X, Zhang W, Wei J, Tang S, Wu H, Yang H. Exploration of the mechanism of traditional Chinese medicine by AI approach using unsupervised machine learning for cellular functional similarity of compounds in heterogeneous networks, XiaoErFuPi granules as an example. Pharmacological Research. 2020 Oct 1; 160:105077.
14] Wills RB, Bone K, Morgan M. Herbal products: active constituents, modes of action and quality control. Nutrition research reviews. 2000 Jun; 13(1):47-77.
15] Xiang H, Liu Y, Zhang B, Huang J, Li Y, Yang B, Huang Z, Xiang F, Zhang H. The antidepressant effects and mechanism of action of total saponins from the caudexes and leaves of Panax notoginseng in animal models of depression. Phytomedicine. 2011 Jun 15; 18(8-9):731-8.
16] Hayashi T, Tsai SY, Mori T, Fujimoto M, Su TP. Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders. Expert opinion on therapeutic targets. 2011 May 1; 15(5):557-77.
17] Kim Y, Lee HY, Choi YJ, Cho SH. Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss. Journal of Ginseng Research. 2020 Jul 1; 44(4):603-10.
18] Kakkar S, Bais S. A review on protocatechuic acid and its pharmacological potential. International Scholarly Research Notices. 2014; 2014.
19] Gorzalczany S, Marrassini C, Miño J, Acevedo C, Ferraro G. Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis. Journal of ethnopharmacology. 2011 Apr 12; 134(3):733-8.
20] Chuang HW, Wei IH, Lin FY, Li CT, Chen KT, Tsai MH, Huang CC. Roles of Akt and ERK in mTOR-Dependent Antidepressant Effects of Vanillic Acid. ACS omega. 2020 Feb 13; 5(7):3709-16.
21] Khoshnam SE, Sarkaki A, Khorsandi L, Winlow W, Badavi M, Moghaddam HF, Farbood Y. Vanillic acid attenuates effects of transient bilateral common carotid occlusion and reperfusion in rats. Biomedicine & Pharmacotherapy. 2017 Dec 1; 96:667-74.
22] de los Angeles Yrbas M, Morucci F, Alonso R, Gorzalczany S. Pharmacological mechanism underlying the antinociceptive activity of vanillic acid. Pharmacology Biochemistry and Behavior. 2015 May 1; 132:88-95.
23] Morucci F, Lopez P, Miño J, Ferraro G, Gorzalczany S. Antinociceptive activity of aqueous extract and isolated compounds of Lithrea molleoides. Journal of ethnopharmacology. 2012 Jul 13; 142(2):401-6.
24] Kumar S, Prahalathan P, Raja B. Antihypertensive and antioxidant potential of vanillic acid, a phenolic compound in L-NAME-induced hypertensive rats: a dose-dependence study. Redox Report. 2011 Sep 1; 16(5):208-15.
25] Saravanakumar M, Raja B, Manivannan J, Silambarasan T, Prahalathan P, Kumar S, Mishra SK. Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation. British Journal of Nutrition. 2015 Nov; 114(9):1385-94.
26] Raja B, Saravanakumar M, Sathya G. Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet. Molecular and cellular biochemistry. 2012 Jul; 366(1):21-30.
27] Shakeel M, Jabeen F, Qureshi NA, Fakhr-e-Alam M. Toxic effects of titanium dioxide nanoparticles and titanium dioxide bulk salt in the liver and blood of male Sprague-Dawley rats assessed by different assays. Biological trace element research. 2016 Oct; 173(2):405-26.
28] Robles-Vera I, Toral M, Romero M, Jiménez R, Sánchez M, Pérez-Vizcaíno F, Duarte J. Antihypertensive effects of probiotics. Current hypertension reports. 2017 Apr 1; 19(4):26.
29] Kim SJ, Kim MC, Um JY, Hong SH. The beneficial effect of vanillic acid on ulcerative colitis. Molecules. 2010 Oct; 15(10):7208-17.
30] Wang K, Jin X, Li Q, Sawaya AC, Le Leu RK, Conlon MA, Wu L, Hu F. Propolis from different geographic origins decreases intestinal inflammation and Bacteroides spp. populations in a model of DSS‐Induced colitis. Molecular Nutrition & Food Research. 2018 Sep; 62(17):1800080.
31] Larrosa M, Luceri C, Vivoli E, Pagliuca C, Lodovici M, Moneti G, Dolara P. Polyphenol metabolites from colonic microbiota exert anti‐inflammatory activity on different inflammation models. Molecular nutrition & food research. 2009 Aug; 53(8):1044-54.
32] Somani SJ, Modi KP, Majumdar AS, Sadarani BN. Phytochemicals and their potential usefulness in inflammatory bowel disease. Phytotherapy research. 2015 Mar; 29(3):339-50.
33] Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW. Hypoxia-inducible factor (HIF-1) α: its protein stability and biological functions. Experimental & molecular medicine. 2004 Feb; 36(1):1-2.
34] Gong J, Zhou S, Yang S. Vanillic acid suppresses HIF-1α expression via inhibition of mTOR/p70S6K/4E-BP1 and Raf/MEK/ERK pathways in human colon cancer HCT116 cells. International journal of molecular sciences. 2019 Jan; 20(3):465.
35] Tang XD, Zhou X, Zhou KY. Dauricine inhibits insulin-like growth factor-I-induced hypoxia inducible factor 1α protein accumulation and vascular endothelial growth factor expression in human breast cancer cells. Acta Pharmacologica Sinica. 2009 May; 30(5):605-16.
36] Velli SK, Sundaram J, Murugan M, Balaraman G, Thiruvengadam D. Protective effect of vanillic acid against benzo (a) pyrene induced lung cancer in Swiss albino mice. Journal of biochemical and molecular toxicology. 2019 Oct; 33(10):e22382.
37] Kumnerdkhonkaen P, Saenglee S, Asgar MA, Senawong G, Khongsukwiwat K, Senawong T. Antiproliferative activities and phenolic acid content of water and ethanolic extracts of the powdered formula of Houttuynia cordata Thunb. fermented broth and Phyllanthus emblica Linn. fruit. BMC complementary and alternative medicine. 2018 Dec 1; 18(1):130.
38] Reddy KK, Ravinder T, Kanjilal S. Synthesis and evaluation of antioxidant and antifungal activities of novel ricinoleate-based lipoconjugates of phenolic acids. Food chemistry. 2012 Oct 15; 134(4):2201-7.
39] Vishnu KV, Kumar KA, Chatterjee NS, Lekshmi RG, Sreerekha PR, Mathew S, Ravishankar CN. Sardine oil loaded vanillic acid grafted chitosan microparticles, a new functional food ingredient: attenuates myocardial oxidative stress and apoptosis in cardiomyoblast cell lines (H9c2). Cell Stress and Chaperones. 2018 Mar; 23(2):213-22.
40] Mandras N, Nostro A, Roana J, Scalas D, Banche G, Ghisetti V, Del Re S, Fucale G, Cuffini AM, Tullio V. Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida. BMC complementary and alternative medicine. 2016 Dec; 16(1):1-7.
41] Itoh A, Isoda K, Kondoh M, Kawase M, Kobayashi M, Tamesada M, Yagi K. Hepatoprotective effect of syringic acid and vanillic acid on concanavalin a-induced liver injury. Biological and Pharmaceutical Bulletin. 2009 Jul 1; 32(7):1215-9.
42] Dhananjaya BL, Nataraju A, Gowda CR, Sharath BK, D’souza CJ. Vanillic acid as a novel specific inhibitor of snake venom 5′-nucleotidase: a pharmacological tool in evaluating the role of the enzyme in snake envenomation. Biochemistry (moscow). 2009 Dec; 74(12):1315-9.
43] Maschio BH, Gentil BC, Caetano EL, Rodrigues LS, Laurino LF, Spim SR, Jozala AF, Dos Santos CA, Grotto D, Gerenutti M. Characterization of the effects of the shiitake culinary-medicinal mushroom, lentinus edodes (agaricomycetes), on severe gestational diabetes mellitus in rats. International journal of medicinal mushrooms. 2017; 19(11).
44] Janel N, Noll C. Protection and reversal of hepatic fibrosis by polyphenols. In Polyphenols in Human Health and Disease 2014 Jan 1 (pp. 665-679). Academic Press.
45] Hwang JY, Lin JT, Liu SC, Hu CC, Shyu YS, Yang DJ. Protective role of litchi (Litchi chinensis Sonn.) flower extract against cadmium-and lead-induced cytotoxicity and transforming growth factor β1-stimulated expression of smooth muscle α-actin estimated with rat liver cell lines. Journal of Functional Foods. 2013 Apr 1; 5(2):698-705.
46] Jiang R, Xu XH, Wang K, Yang XZ, Bi YF, Yan Y, Liu JZ, Chen XN, Wang ZZ, Guo XL, Zhao DQ. Ethyl acetate extract from Panax ginseng CA Meyer and its main constituents inhibit α-melanocyte-stimulating hormone-induced melanogenesis by suppressing oxidative stress in B16 mouse melanoma cells. Journal of ethnopharmacology. 2017 Aug 17; 208:149-56.
47] Park J, Cho SY, Kang J, Park WY, Lee S, Jung Y, Kang MW, Kwak HJ, Um JY. Vanillic Acid Improves Comorbidity of Cancer and Obesity through STAT3 Regulation in High-Fat-Diet-Induced Obese and B16BL6 Melanoma-Injected Mice. Biomolecules. 2020 Aug; 10(8):1098.
48] Basciano H, Federico L, Adeli K. Fructose, insulin resistance, and metabolic dyslipidemia. Nutrition & metabolism. 2005 Dec; 2(1):1-4.
49] Vinothiya K, Ashokkumar N. Modulatory effect of vanillic acid on antioxidant status in high fat diet-induced changes in diabetic hypertensive rats. Biomedicine & Pharmacotherapy. 2017 Mar 1; 87:640-52.
50] Riachi LG, De Maria CA. Yerba mate: An overview of physiological effects in humans. Journal of Functional Foods. 2017 Nov 1; 38:308-20.
51] Ali M, Paul S, Tanvir EM, Hossen M, Rumpa NE, Saha M, Bhoumik NC, Islam A, Hossain M, Alam N, Gan SH. Antihyperglycemic, antidiabetic, and antioxidant effects of Garcinia pedunculata in rats. Evidence-Based Complementary and Alternative Medicine. 2017 Jan 1; 2017.
52] Tlili N, Feriani A, Saadoui E, Nasri N, Khaldi A. Capparis spinosa leaves extract: Source of bioantioxidants with nephroprotective and hepatoprotective effects. Biomedicine & Pharmacotherapy. 2017 Mar 1; 87:171-9.
Statistics
1040 Views | 271 Downloads
How to Cite
1.
Ingole A, Kadam M, Dalu AP, Kute SM, Mange PR, Theng VD, Lahane OR, Nikas AP, Kawal YV, Nagrik SU, Patil PA. A Review of the Pharmacological Characteristics of Vanillic Acid. JDDT [Internet]. 15Apr.2021 [cited 8Dec.2022];11(2-S):200-4. Available from: http://jddtonline.info/index.php/jddt/article/view/4823