Drug Utilization Evaluation of High Alert Medications in Intensive Care Units of Tertiary Care Teaching Hospital

  • Meda Venkata Subbaiah Associate professor in clinical pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, Utukur, Kadapa-516003. Andhra Pradesh, India
  • K Leela Prasad Babu Assistant professor, Department of General Medicine, Rajiv Institute Of Medical Sciences (RIMS), Kadapa-516003. Andhra Pradesh, India
  • Dudekula Manohar Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India
  • Adluru Sumalatha Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India
  • Pinjari Mohammed Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India
  • Budigireddy Mahitha Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India

Abstract

Introduction: The utilization of HAMs is crucial in emergency and intensive care departments, as they can cause a significant amount of damage to the patient and health care members if we could not follow the standard treatment guidelines. Drug utilization evaluation/review involves a comprehensive review of the patient’s prescription and medication data before, during, and after dispensing to ensure appropriate medication decision making and positive patient outcomes.


Objective: This study was taken up given finding the utilization patterns and rectifying the issues with the usage of high alert medications (HAMs) and improving their utilization.


Methodology: A cross-sectional study was conducted for 6 months at a south Indian tertiary care hospital. Treatment guidelines were prepared to compare the actual drug use. Data were collected both retrospectively and prospectively by patients and care taker’s interview, medication chart review, and discussion with prescribers and applied WHO DUE indicators to evaluate utilization patterns.


Results: Of 362 cases, 57.73 % were males/ and the majority geriatrics. Among all HAMs Insulin is frequently prescribed (34.5 %) and the costly drug is Enoxaparin. Generic names were used in writing prescriptions and parenteral formulations were mostly used. Around 9 ADRs were identified and managed, and a total of 133 moderate to severe Drug-Drug Interactions were found, of them, only 2 were actual.


Conclusion: With this study, we conclude that the use of HAMs was found to be appropriate as per the guidelines as we observed very few DRPs with the study drugs.


Keywords: HAM, DRP’s, DUE, ICU, DDD

Keywords: HAM, DRP’s, DUE, ICU, DDD

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Author Biographies

Meda Venkata Subbaiah, Associate professor in clinical pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, Utukur, Kadapa-516003. Andhra Pradesh, India

Associate professor in clinical pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, Utukur, Kadapa-516003. Andhra Pradesh, India

K Leela Prasad Babu, Assistant professor, Department of General Medicine, Rajiv Institute Of Medical Sciences (RIMS), Kadapa-516003. Andhra Pradesh, India

Assistant professor, Department of General Medicine, Rajiv Institute Of Medical Sciences (RIMS), Kadapa-516003. Andhra Pradesh, India

Dudekula Manohar, Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India

Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India

Adluru Sumalatha, Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India

Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India

Pinjari Mohammed, Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India

Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India

Budigireddy Mahitha, Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India

Pharm.D Interns of P Rami Reddy Memorial College of Pharmacy, P Rami Reddy Memorial College of Pharmacy, Prakruthi Nagar, utukur, Kadapa-516003.Andhra Pradesh, India

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Subbaiah M, Babu K, Manohar D, Sumalatha A, Mohammed P, Mahitha B. Drug Utilization Evaluation of High Alert Medications in Intensive Care Units of Tertiary Care Teaching Hospital. JDDT [Internet]. 20Feb.2021 [cited 4Mar.2021];11(1-s):94-01. Available from: http://jddtonline.info/index.php/jddt/article/view/4749