Corona Viruses and Human Leukocyte Antigen (HLA) alleles
Abstract
Major histocompatibility complex (MHC) is consisted of cluster of genes known as human leukocyte antigen HLA, these genes are committed to process and present antigens to T lymphocyte. Corona viruses, belonging to a genus of the corona viridae family, are enveloped viruses containing single stranded RNA 27-32 kb. This study was conducted to highlight some observations that may help other researcher for rapid research advances; the new corona virus genome sequence was obtained from Virus pathogen database, the spike protein (surface glycoprotein) was aligned with SPIKE_CVHSA Spike glycoprotein OS=Human SARS coronavirus OX=694009 GN=S PE=1 SV=1 which was retrieved from Uniprot data base Distribution of HLA alleles was obtained from allele frequencies database, IEDB server was used for MHC 1 prediction. The distribution of HLA-A alleles among population revealed that, the most common wasHLA-A*11:01. The affinity prediction of HLA-A*03:01(AAAYFVGYLK) and HLA-A*11:01(AAYFVGYLK) alleles to the spike peptide were positive. The two positive predicted peptides for both 2 alleles showed mutation of K245Q, This mutation may affect the binding affinity of the protein peptides to HLA-A alleles.
Keywords: HLA. MHC, alleles, Corona viruses, SARS, APS
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