Assessment of Modern Excipients in Controlled Delivery of Proteins and Peptides
Abstract
Polymeric micelles are highly proficient of modulating the function, distribution of drugs in the body, and can overcome biological barriers hence provoked as novel nanomedicine via various formulations. Current review emphasis on application of several polymers, biomaterials, lipids for the preparation of polymeric micelles formed by several molecular interactions between the block co-polymers and encapsulated molecules. Micellar carriers will be selected on basis of the type of polymer/payload interaction, which includes biological interface focused on the internal chemistry and fabrication of block-co polymers. Several features of these carriers can be manipulated to catering a broad range of drugs through active sensing of body targets. The fine-tuning of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level. To end with, the future perspective and impending challenges for polymeric micelles as nanomedicine are elaborated, anticipating prompting further innovations.
Keywords: Proteins, Peptides, Co-block Polymers, Lipids, Controlled, Drug Delivery.
Keywords:
Proteins, Peptides, Co-block Polymers, Lipids, Controlled Drug Delivery
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References
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3. Lv J, Tan E, Wang Y, Fan Q, Yu J, Cheng Y. Tailoring guanidyl-rich polymers for efficient cytosolic protein delivery. Journal of Controlled Release. 2020 Apr 10;320:412-20.
4. Ahmed, O. A. A., Kurakula, M., Banjar, Z. M., Afouna, M. I., & Zidan, A. S. Quality by design coupled with near infrared in formulation of transdermal glimepiride liposomal films. Journal of Pharmaceutical Sciences, 2015; 104(6):2062–2075. https://doi.org/10.1002/jps.24448
5. Alhakamy, N. A., Ahmed, O. A. A., Kurakula, M., Caruso, G., Caraci, F., Asfour, H. Z., Alfarsi, A., Eid, B. G., Mohamed, A. I., Alruwaili, N. K., Abdulaal, W. H., Fahmy, U. A., Alhadrami, H. A., Eldakhakhny, B. M., & Abdel-Naim, A. B. Chitosan-based microparticles enhance ellagic acid’s colon targeting and proapoptotic activity. Pharmaceutics, 2020; 12(7):1–14. https://doi.org/10.3390/pharmaceutics12070652
6. Lv J, Tan E, Wang Y, Fan Q, Yu J, Cheng Y. Tailoring guanidyl-rich polymers for efficient cytosolic protein delivery. Journal of Controlled Release. 2020 Apr 10;320:412-20.
7. Asfour MH. Advanced trends in protein and peptide drug delivery: a special emphasis on aquasomes and microneedles techniques. Drug Delivery and Translational Research. 2020 Apr 26:1-23.
8. Alhakamy, N. A., Fahmy, U. A., Ahmed, O. A. A., Caruso, G., Caraci, F., Asfour, H. Z., Bakhrebah, M. A., Alomary, M. N., Abdulaal, W. H., Okbazghi, S. Z., Abdel-Naim, A. B., Eid, B. G., Aldawsari, H. M., Kurakula, M., & Mohamed, A. I. Chitosan coated microparticles enhance simvastatin colon targeting and pro-apoptotic activity. Marine Drugs, 2020; 18(4):226. https://doi.org/10.3390/md18040226
9. Messina KM. Polymeric Materials to Improve the Stability and Delivery of Insulin and Glucagon (Doctoral dissertation, UCLA).
10. Hasnain, M. S., Kiran, V., Kurakula, M., Rao, G. K., Tabish, M., & Nayak, A. K. Use of alginates for drug delivery in dentistry. In Alginates in Drug Delivery (2020; pp. 387–404). Elsevier. https://doi.org/10.1016/b978-0-12-817640-5.00015-7
11. Wu C, Mu H. Lipid and PLGA Microparticles for Sustained Delivery of Protein and Peptide Drugs. Pharmaceutical Nanotechnology. 2020 Feb 1; 8(1):22-32.
12. Hasnain, M. S., Nayak, A. K., Kurakula, M., & Hoda, M. N. Alginate nanoparticles in drug delivery. In Alginates in Drug Delivery (2020; pp. 129–152). Elsevier. https://doi.org/10.1016/b978-0-12-817640-5.00006-6
13. Lee YW, Luther DC, Goswami R, Jeon T, Clark V, Elia J, Gopalakrishnan S, Rotello VM. Direct cytosolic delivery of proteins through coengineering of proteins and polymeric delivery vehicles. Journal of the American Chemical Society. 2020 Feb 12; 142(9):4349-55.
14. Hosny, K. M., Aldawsari, H. M., Bahmdan, R. H., Sindi, A. M., Kurakula, M., Alrobaian, M. M., Aldryhim, A. Y., Alkhalidi, H. M., Bahmdan, H. H., Khallaf, R. A., & El Sisi, A. M. Preparation, Optimization, and Evaluation of Hyaluronic Acid-Based Hydrogel Loaded with Miconazole Self-Nanoemulsion for the Treatment of Oral Thrush. AAPS PharmSciTech, 2019; 20(7):297. https://doi.org/10.1208/s12249-019-1496-7
15. Wang Y, Zhang W, Gong C, Liu B, Li Y, Wang L, Su Z, Wei G. Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels. Soft Matter. 2020; 16(44):10029-45.
16. Kurakula, M., & A. Ahmed, T. Co-Delivery of Atorvastatin Nanocrystals in PLGA based in situ Gel for Anti-Hyperlipidemic Efficacy. Current Drug Delivery, 2015; 13(2):211–220. https://doi.org/10.2174/1567201813666151109102718
17. Wang Y, Zhang W, Gong C, Liu B, Li Y, Wang L, Su Z, Wei G. Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels. Soft Matter. 2020; 16(44):10029-45.
18. Kurakula, M., Ahmed, O. A. A., Fahmy, U. A., & Ahmed, T. A. Solid lipid nanoparticles for transdermal delivery of avanafil: optimization, formulation, in-vitro and ex-vivo studies. Journal of Liposome Research, 2016; 26(4):288–296. https://doi.org/10.3109/08982104.2015.1117490
19. Asadzadeh H, Moosavi A, Arghavani JH. The effect of chitosan and PEG polymers on stabilization of GF-17 structure: A molecular dynamics study. Carbohydrate Polymers. 2020 Mar 7:116124.
20. Kurakula, M., El-Helw, A. M., Sobahi, T. R., & Abdelaal, M. Y. Chitosan based atorvastatin nanocrystals: Effect of cationic charge on particle size, formulation stability, and in-vivo efficacy. International Journal of Nanomedicine, 2015; 10:321–334. https://doi.org/10.2147/IJN.S77731
21. Mondal S, Das S, Nandi AK. A review on recent advances in polymer and peptide hydrogels. Soft Matter. 2020; 16(6):1404-54.
22. Das SS, Bharadwaj P, Bilal M, Barani M, Rahdar A, Taboada P, Bungau S, Kyzas GZ. Stimuli-responsive polymeric nanocarriers for drug delivery, imaging, and theragnosis. Polymers. 2020 Jun; 12(6):1397.
23. Kurakula, M., & Koteswara Rao, G. S. N. Moving polyvinyl pyrrolidone electrospun nanofibers and bioprinted scaffolds toward multidisciplinary biomedical applications. European Polymer Journal, 2020; 136:109919. https://doi.org/10.1016/j.eurpolymj.2020.109919
24. Lv J, Liu C, Lv K, Wang H, Cheng Y. Boronic acid-rich dendrimer for efficient intracellular peptide delivery. Science China Materials. 2020 Apr; 63(4):620-8.
25. Kavand A, Anton N, Vandamme T, Serra CA, Chan-Seng D. Synthesis and functionalization of hyperbranched polymers for targeted drug delivery. Journal of Controlled Release. 2020 May 10; 321:285-311.
26. Kurakula, M., Naveen, N. R., & Yadav, K. S. Formulations for Polymer Coatings. Polymer Coatings, 2020; 415–443. https://doi.org/10.1002/9781119655145.ch19
27. Bukchin A, Sanchez-Navarro M, Carrera A, Teixidó M, Carcaboso AM, Giralt E, Sosnik A. Amphiphilic Polymeric Nanoparticles Modified with a Retro-Enantio Peptide Shuttle Target the Brain of Mice. Chemistry of Materials. 2020 Aug 24; 32(18):7679-93.
28. Kurakula, M., & Raghavendra Naveen, N. In situ gel loaded with chitosan-coated simvastatin nanoparticles: Promising delivery for effective anti-proliferative activity against tongue carcinoma. Marine Drugs, 2020; 18(4):201. https://doi.org/10.3390/md18040201
29. Mukhopadhyay S, Prasad AB, Mehta CH, Nayak UY. Antimicrobial peptide polymers: No escape to ESKAPE pathogens—A review. World Journal of Microbiology and Biotechnology. 2020 Sep; 36(9):1-4.
30. Ke L, Cai P, Wu YL, Chen X. Polymeric nonviral gene delivery systems for cancer immunotherapy. Advanced Therapeutics. 2020 Jun; 3(6):1900213.
31. Kurakula, M., Rao, G. K., Kiran, V., Hasnain, M. S., & Nayak, A. K. Alginate-based hydrogel systems for drug releasing in wound healing. In Alginates in Drug Delivery (2020; pp. 323–358). Elsevier. https://doi.org/10.1016/b978-0-12-817640-5.00013-3
32. Albuquerque T, Faria R, Sousa Â, Neves AR, Queiroz JA, Costa D. Polymer-peptide ternary systems as a tool to improve the properties of plasmid DNA vectors in gene delivery. Journal of Molecular Liquids. 2020 Apr 17:113157.
33. Rao, G. S. N. K., Kurakula, M., & Yadav, K. S. Application of Electrospun Materials in Gene Delivery. Electrospun Materials and Their Allied Applications, 2020; 265–306
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Munjulury V, Calico R. Assessment of Modern Excipients in Controlled Delivery of Proteins and Peptides. JDDT [Internet]. 15Dec.2020 [cited 20Apr.2024];10(6-s):134-8. Available from: https://jddtonline.info/index.php/jddt/article/view/4631
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