Assessment of Modern Excipients in Controlled Delivery of Proteins and Peptides

  • Venkata Sai Dheeraj Munjulury Department of Formulation R&D, Cipla Ltd., 400083, Mumbai, India
  • Robertina Calico Department of Polymer Science, University of Bologna, 40126 Bologna, Italy

Abstract

Polymeric micelles are highly proficient of modulating the function, distribution of drugs in the body, and can overcome biological barriers hence provoked as novel nanomedicine via various formulations. Current review emphasis on application of several polymers, biomaterials, lipids for the preparation of polymeric micelles formed by several molecular interactions between the block co-polymers and encapsulated molecules.  Micellar carriers will be selected on basis of the type of polymer/payload interaction, which includes biological interface focused on the internal chemistry and fabrication of block-co polymers. Several features of these carriers can be manipulated to catering a broad range of drugs through active sensing of body targets. The fine-tuning of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level. To end with, the future perspective and impending challenges for polymeric micelles as nanomedicine are elaborated, anticipating prompting further innovations. 


Keywords:  Proteins, Peptides, Co-block Polymers, Lipids, Controlled, Drug Delivery.

Keywords: Proteins, Peptides, Co-block Polymers, Lipids, Controlled Drug Delivery

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Author Biographies

Venkata Sai Dheeraj Munjulury, Department of Formulation R&D, Cipla Ltd., 400083, Mumbai, India

Department of Formulation R&D, Cipla Ltd., 400083, Mumbai, India

Robertina Calico, Department of Polymer Science, University of Bologna, 40126 Bologna, Italy

Department of Polymer Science, University of Bologna, 40126 Bologna, Italy

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Munjulury V, Calico R. Assessment of Modern Excipients in Controlled Delivery of Proteins and Peptides. JDDT [Internet]. 15Dec.2020 [cited 21Jan.2021];10(6-s):134-8. Available from: http://jddtonline.info/index.php/jddt/article/view/4631