Assessment of Modern Excipients in Controlled Delivery of Proteins and Peptides
Polymeric micelles are highly proficient of modulating the function, distribution of drugs in the body, and can overcome biological barriers hence provoked as novel nanomedicine via various formulations. Current review emphasis on application of several polymers, biomaterials, lipids for the preparation of polymeric micelles formed by several molecular interactions between the block co-polymers and encapsulated molecules. Micellar carriers will be selected on basis of the type of polymer/payload interaction, which includes biological interface focused on the internal chemistry and fabrication of block-co polymers. Several features of these carriers can be manipulated to catering a broad range of drugs through active sensing of body targets. The fine-tuning of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level. To end with, the future perspective and impending challenges for polymeric micelles as nanomedicine are elaborated, anticipating prompting further innovations.
Keywords: Proteins, Peptides, Co-block Polymers, Lipids, Controlled, Drug Delivery.
2. Abdelhady, S., Honsy, K. M., & Kurakula, M. Electro Spun- Nanofibrous Mats: A Modern Wound Dressing Matrix with a Potential of Drug Delivery and Therapeutics. Journal of Engineered Fibers and Fabrics, 2015; 10(4):155892501501000. https://doi.org/10.1177/155892501501000411
3. Lv J, Tan E, Wang Y, Fan Q, Yu J, Cheng Y. Tailoring guanidyl-rich polymers for efficient cytosolic protein delivery. Journal of Controlled Release. 2020 Apr 10;320:412-20.
4. Ahmed, O. A. A., Kurakula, M., Banjar, Z. M., Afouna, M. I., & Zidan, A. S. Quality by design coupled with near infrared in formulation of transdermal glimepiride liposomal films. Journal of Pharmaceutical Sciences, 2015; 104(6):2062–2075. https://doi.org/10.1002/jps.24448
5. Alhakamy, N. A., Ahmed, O. A. A., Kurakula, M., Caruso, G., Caraci, F., Asfour, H. Z., Alfarsi, A., Eid, B. G., Mohamed, A. I., Alruwaili, N. K., Abdulaal, W. H., Fahmy, U. A., Alhadrami, H. A., Eldakhakhny, B. M., & Abdel-Naim, A. B. Chitosan-based microparticles enhance ellagic acid’s colon targeting and proapoptotic activity. Pharmaceutics, 2020; 12(7):1–14. https://doi.org/10.3390/pharmaceutics12070652
6. Lv J, Tan E, Wang Y, Fan Q, Yu J, Cheng Y. Tailoring guanidyl-rich polymers for efficient cytosolic protein delivery. Journal of Controlled Release. 2020 Apr 10;320:412-20.
7. Asfour MH. Advanced trends in protein and peptide drug delivery: a special emphasis on aquasomes and microneedles techniques. Drug Delivery and Translational Research. 2020 Apr 26:1-23.
8. Alhakamy, N. A., Fahmy, U. A., Ahmed, O. A. A., Caruso, G., Caraci, F., Asfour, H. Z., Bakhrebah, M. A., Alomary, M. N., Abdulaal, W. H., Okbazghi, S. Z., Abdel-Naim, A. B., Eid, B. G., Aldawsari, H. M., Kurakula, M., & Mohamed, A. I. Chitosan coated microparticles enhance simvastatin colon targeting and pro-apoptotic activity. Marine Drugs, 2020; 18(4):226. https://doi.org/10.3390/md18040226
9. Messina KM. Polymeric Materials to Improve the Stability and Delivery of Insulin and Glucagon (Doctoral dissertation, UCLA).
10. Hasnain, M. S., Kiran, V., Kurakula, M., Rao, G. K., Tabish, M., & Nayak, A. K. Use of alginates for drug delivery in dentistry. In Alginates in Drug Delivery (2020; pp. 387–404). Elsevier. https://doi.org/10.1016/b978-0-12-817640-5.00015-7
11. Wu C, Mu H. Lipid and PLGA Microparticles for Sustained Delivery of Protein and Peptide Drugs. Pharmaceutical Nanotechnology. 2020 Feb 1; 8(1):22-32.
12. Hasnain, M. S., Nayak, A. K., Kurakula, M., & Hoda, M. N. Alginate nanoparticles in drug delivery. In Alginates in Drug Delivery (2020; pp. 129–152). Elsevier. https://doi.org/10.1016/b978-0-12-817640-5.00006-6
13. Lee YW, Luther DC, Goswami R, Jeon T, Clark V, Elia J, Gopalakrishnan S, Rotello VM. Direct cytosolic delivery of proteins through coengineering of proteins and polymeric delivery vehicles. Journal of the American Chemical Society. 2020 Feb 12; 142(9):4349-55.
14. Hosny, K. M., Aldawsari, H. M., Bahmdan, R. H., Sindi, A. M., Kurakula, M., Alrobaian, M. M., Aldryhim, A. Y., Alkhalidi, H. M., Bahmdan, H. H., Khallaf, R. A., & El Sisi, A. M. Preparation, Optimization, and Evaluation of Hyaluronic Acid-Based Hydrogel Loaded with Miconazole Self-Nanoemulsion for the Treatment of Oral Thrush. AAPS PharmSciTech, 2019; 20(7):297. https://doi.org/10.1208/s12249-019-1496-7
15. Wang Y, Zhang W, Gong C, Liu B, Li Y, Wang L, Su Z, Wei G. Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels. Soft Matter. 2020; 16(44):10029-45.
16. Kurakula, M., & A. Ahmed, T. Co-Delivery of Atorvastatin Nanocrystals in PLGA based in situ Gel for Anti-Hyperlipidemic Efficacy. Current Drug Delivery, 2015; 13(2):211–220. https://doi.org/10.2174/1567201813666151109102718
17. Wang Y, Zhang W, Gong C, Liu B, Li Y, Wang L, Su Z, Wei G. Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels. Soft Matter. 2020; 16(44):10029-45.
18. Kurakula, M., Ahmed, O. A. A., Fahmy, U. A., & Ahmed, T. A. Solid lipid nanoparticles for transdermal delivery of avanafil: optimization, formulation, in-vitro and ex-vivo studies. Journal of Liposome Research, 2016; 26(4):288–296. https://doi.org/10.3109/08982104.2015.1117490
19. Asadzadeh H, Moosavi A, Arghavani JH. The effect of chitosan and PEG polymers on stabilization of GF-17 structure: A molecular dynamics study. Carbohydrate Polymers. 2020 Mar 7:116124.
20. Kurakula, M., El-Helw, A. M., Sobahi, T. R., & Abdelaal, M. Y. Chitosan based atorvastatin nanocrystals: Effect of cationic charge on particle size, formulation stability, and in-vivo efficacy. International Journal of Nanomedicine, 2015; 10:321–334. https://doi.org/10.2147/IJN.S77731
21. Mondal S, Das S, Nandi AK. A review on recent advances in polymer and peptide hydrogels. Soft Matter. 2020; 16(6):1404-54.
22. Das SS, Bharadwaj P, Bilal M, Barani M, Rahdar A, Taboada P, Bungau S, Kyzas GZ. Stimuli-responsive polymeric nanocarriers for drug delivery, imaging, and theragnosis. Polymers. 2020 Jun; 12(6):1397.
23. Kurakula, M., & Koteswara Rao, G. S. N. Moving polyvinyl pyrrolidone electrospun nanofibers and bioprinted scaffolds toward multidisciplinary biomedical applications. European Polymer Journal, 2020; 136:109919. https://doi.org/10.1016/j.eurpolymj.2020.109919
24. Lv J, Liu C, Lv K, Wang H, Cheng Y. Boronic acid-rich dendrimer for efficient intracellular peptide delivery. Science China Materials. 2020 Apr; 63(4):620-8.
25. Kavand A, Anton N, Vandamme T, Serra CA, Chan-Seng D. Synthesis and functionalization of hyperbranched polymers for targeted drug delivery. Journal of Controlled Release. 2020 May 10; 321:285-311.
26. Kurakula, M., Naveen, N. R., & Yadav, K. S. Formulations for Polymer Coatings. Polymer Coatings, 2020; 415–443. https://doi.org/10.1002/9781119655145.ch19
27. Bukchin A, Sanchez-Navarro M, Carrera A, Teixidó M, Carcaboso AM, Giralt E, Sosnik A. Amphiphilic Polymeric Nanoparticles Modified with a Retro-Enantio Peptide Shuttle Target the Brain of Mice. Chemistry of Materials. 2020 Aug 24; 32(18):7679-93.
28. Kurakula, M., & Raghavendra Naveen, N. In situ gel loaded with chitosan-coated simvastatin nanoparticles: Promising delivery for effective anti-proliferative activity against tongue carcinoma. Marine Drugs, 2020; 18(4):201. https://doi.org/10.3390/md18040201
29. Mukhopadhyay S, Prasad AB, Mehta CH, Nayak UY. Antimicrobial peptide polymers: No escape to ESKAPE pathogens—A review. World Journal of Microbiology and Biotechnology. 2020 Sep; 36(9):1-4.
30. Ke L, Cai P, Wu YL, Chen X. Polymeric nonviral gene delivery systems for cancer immunotherapy. Advanced Therapeutics. 2020 Jun; 3(6):1900213.
31. Kurakula, M., Rao, G. K., Kiran, V., Hasnain, M. S., & Nayak, A. K. Alginate-based hydrogel systems for drug releasing in wound healing. In Alginates in Drug Delivery (2020; pp. 323–358). Elsevier. https://doi.org/10.1016/b978-0-12-817640-5.00013-3
32. Albuquerque T, Faria R, Sousa Â, Neves AR, Queiroz JA, Costa D. Polymer-peptide ternary systems as a tool to improve the properties of plasmid DNA vectors in gene delivery. Journal of Molecular Liquids. 2020 Apr 17:113157.
33. Rao, G. S. N. K., Kurakula, M., & Yadav, K. S. Application of Electrospun Materials in Gene Delivery. Electrospun Materials and Their Allied Applications, 2020; 265–306
34. Bolu BS, Golba B, Sanyal A, Sanyal R. Trastuzumab targeted micellar delivery of docetaxel using dendron–polymer conjugates. Biomaterials Science. 2020; 8(9):2600-10.
35. Ferguson EL, Varache M, Stokniene J, Thomas DW. Polysaccharides for protein and peptide conjugation. InPolymer-Protein Conjugates 2020 Jan 1 (pp. 421-453). Elsevier.
36. Kurakula, M., & Rao, G. S. N. K. Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition. Journal of Drug Delivery Science and Technology, 2020; 60:102046. https://doi.org/10.1016/j.jddst.2020.102046
37. Drucker DJ. Advances in oral peptide therapeutics. Nature reviews Drug discovery. 2020 Apr; 19(4):277-89.
38. Kurakula, M., Sobahi, T. R., El-Helw, A., & Abdelaal, M. Y. Development and validation of a RP-HPLC method for assay of atorvastatin and its application in dissolution studies on thermosensitive hydrogel-based nanocrystals. Tropical Journal of Pharmaceutical Research, 2014; 13(10):1681–1687. https://doi.org/10.4314/tjpr.v13i10.16
39. Fopase R, Bhardwaj A, Yadav VS, Pandey LM. Engineered drug delivery systems: insights of biointerface. InBiointerface Engineering: Prospects in Medical Diagnostics and Drug Delivery 2020 (pp. 1-30). Springer, Singapore.
40. Kirkby M, Hutton AR, Donnelly RF. Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations. Pharmaceutical Research. 2020; 37(6).
41. Kurakula, M., Srinivas, C., Kasturi, N., & Diwan, P. V. Formulation and Evaluation of Prednisolone Proliposomal Gel for Effective Topical Pharmacotherapy. International Journal of Pharmaceutical Sciences and Drug Research, 2012; 4(1):35.
42. Vedadghavami A, Zhang C, Bajpayee AG. Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins. Nano today. 2020 Oct 1; 34:100898.
43. Ng YM, Mat Yusuf SN, Chiu HI, Lim V. Redox-Sensitive Linear and Cross-Linked Cystamine-Based Polymers for Colon-Targeted Drug Delivery: Design, Synthesis, and Characterisation. Pharmaceutics. 2020 May; 12(5):461.
44. Mallesh, K., Pasula, N., & Kumar Ranjith, C. P. Piroxicam proliposomal gel: a novel approach for tropical delivery. Journal of Pharmacy Research, 2012; 5(3):1755–1763.
45. Kurakula M, Mohd AB, Rao PA, Diwan PV. Estimation of piroxicam in proliposomal formulation using RPHPLC method. Int. J. Chem. Anal. Sci. 2011; 2:1193. 2011; 1196.
46. Kurakula M, Naveen NR. Prospection of recent chitosan biomedical trends: Evidence from patent analysis (2009–2020). International Journal of Biological Macromolecules. 2020 Oct 15.
47. Hartl N, Adams F, Merkel OM. From Adsorption to Covalent Bonding: Apolipoprotein E Functionalization of Polymeric Nanoparticles for Drug Delivery Across the Blood–Brain Barrier. Advanced Therapeutics. 2020:2000092.
48. Venkatesh, M., & Mallesh, K. Self-Nano Emulsifying Drug Delivery System (SNEDDS) for Oral Delivery of Atorvastatin- Formulation and Bioavailability Studies. Journal of Drug Delivery and Therapeutics, 2013; 3(3):131–140. https://doi.org/10.22270/jddt.v3i3.517
49. Kanazawa T, Taki H, Okada H. Nose-to-brain drug delivery system with ligand/cell-penetrating peptide-modified polymeric nano-micelles for intracerebral gliomas. European Journal of Pharmaceutics and Biopharmaceutics. 2020 May 5.
50. Kurakula M, Mohd AB, Samhuidrom AP, Diwan PV. Estimation of prednisolone in proliposomal formulation using RP HPLC method. Int. J. Res. Pharm. Biomed. Sci. 2011; 2:663.
51. Lu J, Wang H, Tian Z, Hou Y, Lu H. Cryopolymerization of 1, 2-Dithiolanes for the Facile and Reversible Grafting-from Synthesis of Protein–Polydisulfide Conjugates. Journal of the American Chemical Society. 2020 Jan 13; 142(3):1217-21.
52. Xie D, Wang F, Xiang Y, Huang Y. Enhanced nuclear delivery of H1-S6A, F8A peptide by NrTP6-modified polymeric platform. International Journal of Pharmaceutics. 2020 Mar 12:119224.
53. Murali, V. P., Fujiwara, T., Gallop, C., Wang, Y., Wilson, J. A., Atwill, M. T., Kurakula, M., & Bumgardner, J. D. Modified electrospun chitosan membranes for controlled release of simvastatin. International Journal of Pharmaceutics, 2020; 584:119438. https://doi.org/10.1016/j.ijpharm.2020.119438
54. Salameh JW, Zhou L, Ward SM, Santa Chalarca CF, Emrick T, Figueiredo ML. Polymer‐mediated gene therapy: Recent advances and merging of delivery techniques. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2020 Mar; 12(2):e1598.
55. Chen S, Wu L, Ren J, Bemmer VL, Zajicek R, Chen R. Comb-Like Pseudopeptides Enable Very Rapid and Efficient Intracellular Trehalose Delivery for Enhanced Cryopreservation of Erythrocytes. ACS Applied Materials & Interfaces. 2020 Jun 4.
56. Shen W, Wang R, Fan Q, Gao X, Wang H, Shen Y, Li Y, Cheng Y. Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery. CCS Chemistry. 2020 Mar 9:146-57.
57. Gui L, Zhang XH, Qiao ZY, Wang H. Cell‐Penetrating Peptides and Polymers for Improved Drug Delivery. ChemNanoMat.
58. Naguib, Ghada Hussein, Al-Hazmi, F. E., Kurakula, M., Abdulaziz Al-Dharrab, A., Mohamed Hosny, K., Mohammed Alkhalidi, H., Tharwat Hamed, M., Habiballah Hassan, A., Al-Mohammadi, A. M., Mohamed Alnowaiser, A., & Henry Pashley, D. Zein coated zinc oxide nanoparticles: Fabrication and antimicrobial evaluation as dental aid. International Journal of Pharmacology, 2018; 14(8):1051–1059. https://doi.org/10.3923/ijp.2018.1051.1059
59. Mainini F, Eccles MR. Lipid and Polymer-Based Nanoparticle siRNA Delivery Systems for Cancer Therapy. Molecules. 2020 Jan; 25(11):2692.
60. Shakeri S, Ashrafizadeh M, Zarrabi A, Roghanian R, Afshar EG, Pardakhty A, Mohammadinejad R, Kumar A, Thakur VK. Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics. Biomedicines. 2020 Jan; 8(1):13.
61. Kovács AN, Varga N, Juhász Á, Csapó E. Serum protein-hyaluronic acid complex nanocarriers: Structural characterisation and encapsulation possibilities. Carbohydrate Polymers. 2020 Sep 7; 251:117047.
62. Naveen, N. R., Gopinath, C., & Kurakula, M. Okra-thioglycolic acid conjugate-synthesis, characterization, and evaluation as a mucoadhesive polymer. Processes, 2020; 8(3):316. https://doi.org/10.3390/pr8030316
63. Zhang C, Yang L, Wan F, Bera H, Cun D, Rantanen J, Yang M. Quality by Design thinking in the development of long-acting injectable PLGA/PLA-based microspheres for peptide and protein drug delivery. International Journal of Pharmaceutics. 2020 May 19:119441.
64. Uddin S. Peptide Drug/Device Combinations. In Development of Biopharmaceutical Drug-Device Products 2020 (pp. 613-637). Springer, Cham.
65. Raghavendra Naveen, N., Kurakula, M., & Gowthami, B. Process optimization by response surface methodology for preparation and evaluation of methotrexate loaded chitosan nanoparticles. Materials Today: Proceedings. 2020. https://doi.org/10.1016/j.matpr.2020.01.491
66. Wang W, Mattoussi H. Engineering the Bio–Nano Interface Using a Multifunctional Coordinating Polymer Coating. Accounts of Chemical Research. 2020 May 19.
67. Leigh T, Fernandez-Trillo P. Helical polymers for biological and medical applications. Nature Reviews Chemistry. 2020 May 5:1-20.
68. Vanitasagar, S., Srinivas, C., Subhashini, N. J. P., & Mallesh, K. Solid dispersion-a comparative study on the dissolution rate of aceclofenac. International Journal of Pharmacy and Pharmaceutical Sciences, 2012; 4(SUPPL.3):274–278.
69. Ibeanu N, Egbu R, Onyekuru L, Javaheri H, Khaw PT, Williams GR, Brocchini S, Awwad S. Injectables and Depots to Prolong Drug Action of Proteins and Peptides. Pharmaceutics. 2020 Oct; 12(10):999.
70. Acosta S, Ye Z, Aparicio C, Alonso M, Rodríguez-Cabello JC. Dual Self-Assembled Nanostructures from Intrinsically Disordered Protein Polymers with LCST Behavior and Antimicrobial Peptides. Biomacromolecules. 2020 Jul 30; 21(10):4043-52.
71. Gradinati V, Baruffaldi F, Abbaraju S, Laudenbach M, Amin R, Gilger B, Velagaleti P, Pravetoni M. Polymer-mediated delivery of vaccines to treat opioid use disorders and to reduce opioid-induced toxicity. Vaccine. 2020 May 19.
72. Chen C, Richter F, Guerrero-Sanchez C, Traeger A, Schubert US, Feng A, Thang SH. Cell-Penetrating, Peptide-Based RAFT Agent for Constructing Penetration Enhancers. ACS Macro Letters. 2020 Feb 4; 9(2):260-5.
73. Lin JL, Wang ZK, Xu ZY, Wei L, Zhang YC, Wang H, Zhang DW, Zhou W, Zhang YB, Liu Y, Li ZT. Water-Soluble Flexible Organic Frameworks That Include and Deliver Proteins. Journal of the American Chemical Society. 2020 Feb 3; 142(7):3577-82.
74. Meyer CE, Abram SL, Craciun I, Palivan CG. Biomolecule–polymer hybrid compartments: combining the best of both worlds. Physical Chemistry Chemical Physics. 2020.
75. Garg C, Priyam A, Kumar P, Sharma AK, Gupta A. In vitro assessment of core-shell micellar nanostructures of amphiphilic cationic polymer-peptide conjugates as efficient gene and drug carriers. Journal of Pharmaceutical Sciences. 2020 May 28.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).