An Insight to Nanostructured Lipid Carrier System

  • G. Rajalakshmi Associate Professor in Mohamed Sathak A.J College of Pharmacy, Sholinganallur, Chennai 119, India
  • C.K. Dhanapal Professor, Department of Pharmacy, Annamalai University, Chidambaram, Annamalai Nagar 002, India
  • R. Sundhararajan Principal, Mohamed Sathak A.J College of Pharmacy, Shollinganallur, Chennai 119, India


In pharmaceutical field, many drugs are being invented to combat the existing new diseases. The winds of change in the drug scenario are blowing forcefully worldwide. The emergence of new technologies provides an unique opportunities to exploit novel approaches in drug delivery. A shift from conventional drug delivery to novel drug delivery is noticed as shift from conventional drug delivery suffers from various drawbacks, But these new mighty compounds in drug therapy solely are not sufficient to meet the today’s need. There is an urgent need for the smart technology, as the drugs available suffer from serious problems like poor solubility and poor bioavailability. Most of the drugs that are available therapeutically comes under BCS class II ie, poorly soluble and high lipophilc. To assure progress in drug therapy, the development of new drugs merely is not sufficient. Issues arising in delivery of new drugs should also be addressed. Thus there is an emergent need to improve the bioavailability of these drugs, the only remedy or boon for such drugs is the discovery of some smart technologies which can improve the bioavailability of these drugs. Nano drug delivery systems are the one such universal approach which fulfills the lacuna, which exists in conventional drug delivery systems. These Nano drug delivery systems, improves the pharmacokinetic profiles of many drugs. In 1980 K. Eric Drexler developed and popularized the concept of nanotechnology. In this review a deep insight on Nano structured lipid carriers is discussed elaborating its birth, significant qualities compared to other colloidal systems, its structure, characteristics, preparation and application are spotted.

Key words: BCS class, Lipophilic, Nano technology, Nano structured lipid carrier.

Keywords: BCS class, Lipophilic, Nano technology, Nano structured lipid carrier


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Author Biographies

G. Rajalakshmi, Associate Professor in Mohamed Sathak A.J College of Pharmacy, Sholinganallur, Chennai 119, India

Associate Professor in Mohamed Sathak A.J College of Pharmacy, Sholinganallur, Chennai 119, India

C.K. Dhanapal, Professor, Department of Pharmacy, Annamalai University, Chidambaram, Annamalai Nagar 002, India

Professor, Department of Pharmacy, Annamalai University, Chidambaram, Annamalai Nagar 002, India

R. Sundhararajan, Principal, Mohamed Sathak A.J College of Pharmacy, Shollinganallur, Chennai 119, India

Principal, Mohamed Sathak A.J College of Pharmacy, Shollinganallur, Chennai 119, India


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Rajalakshmi G, Dhanapal C, Sundhararajan R. An Insight to Nanostructured Lipid Carrier System. JDDT [Internet]. 15Dec.2020 [cited 21Jan.2021];10(6-s):173-82. Available from: