Medicinal Uses of Maslinic Acid: A Review
Abstract
Maslinic Acid a characteristic compound of the triterpenoid bunch got from olive which forestalls the age of favorable to fiery cytokines and oxidative pressure, found in an assortment of common sources, going from home grown cures utilized in traditional medicine to consumable vegetables and organic products present in the Mediterranean eating routine. A few investigations have demonstrated that maslinic acid a wide scope of pharmacological effects such as Antimalarial Effect, Anti-Proliferative Activity, Antitumor Activity, Antifungal Activity, Antibacterial Activity, Anti-diabetic Effect, Antioxidant effect, Anti-inflammatory Activity, Cardio protective effect, Neuroprotection effect, Antiviral Activity, Antimicrobial Activity.
Keywords: Maslinic acid, Triterpene, edible source, Pharmacological Effects
Keywords:
Maslinic acid, Triterpene, edible source, Pharmacological Effects
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References
1. Lozano MG, Sanchez GM, Juan ME, Planas JM, “Maslinic acid, a natural phytoalexin-type triterpene from olives–a promising nutraceutical” Molecules, 2014; 19:11538–11559.
2. Sánchez GM, Lozano MG, Juan ME, García GA, Planas JM, “Assessment of the safety of maslinic acid, a bioactive compound from Olea europaea L” MNFR, 2013; 57:339–346.
3. Tschesche R, Heesch A, Fugmann R, “Über triterpenoide, III. Mitteil.: Zur kenntnis der crataegolsäure” CB, 1953; 86:626‒629.
4. Moneriz C, Mestres J, Bautista JM, Diez A, Puyet A, “Multi-targeted activity of maslinic acid as an antimalarial natural compound” FEBSJ, 2011; 278(16):2951-61.
5. Juan ME,Planas JM,Ruiz GV, Daniel H, Wenzel U, “Anti-proliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells”BrJN, 2008; 100:36–43.
6. Li C,Yang Z, Zhai C, Qiu W, Li D, Yi Z, Wang L, Tang J, Qian M, Luo J,et al, “Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway” MC, 2010; 73(1):73:13.
7. Jamkhande PG, Pathan SK, Wadher SJ,“In silico PASS analysis and determination of antimycobacterial, antifungal, and antioxidant efficacies of maslinic acid in an extract rich in pentacyclic triterpenoids” IJM, 2016;5(4):417–425.
8. Wen X,Sun H,Liu J, Wu G, Zhang L, Wu X, Ni P, “Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases”BMCL, 2005; 15:4944–4948.
9. Wang R, Wang W, Wang L, Liu R,Ding Y,Du L,”Constituents of the flowers of Punica granatum”Fitoterapia, 2006; 77:534–537.
10. Napetschnig J,Wu H, “Molecular basis of NF-κB signaling” ARB, 2013; 42:443–468.
11. Hussain SA, Rasool SN, Abdul KM, Krushna GS, Akhtar PM, Devi KL, “Maslinic acid protects against isoproterenol-induced cardiotoxicity in albino Wistar rats” JMFood, 2012; 15:741–746.
12. Kagansky N,Levy S,Knobler H, “The role of hyperglycemia in acute stroke” AN, 2001;58: 1209–1212.
13. Xu HX, Zeng FQ,Wan M, Sim KY, “Anti-HIV triterpene acids from Geum japonicum” JNP, 1996; 59(7):643–645.
14. Braca A,Morelli I,M´endez J, Battinelli L, Braghiroli L,Mazzanti G, “Antimicrobial triterpenoids from Licania heteromorpha” PM, 2000; 66(8):768–769.
15. Sanchez TS, Reyes ZFJ, Dıaz MS, et al, “Maslinic acid-enriched diet decreases intestinal tumor genesis in ApcMin/+ mice through transcriptomic and metabolomics reprogramming” PLoS ONE, 2013; 8(3):59392.
16. Marquez MA, Puerta Vazquez A, Fernandez Arche,Ruiz GA,“Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages” FRResearch, 2006; 40(3):295–302.
17. Huang TL, Guan Y, Qian et al., “Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B” EJP, 2011; 672(1–3):169–174.
18. Qian Y, Guan T,Tang X et al., “Maslinic acid, a natural triterpenoid compound from Olea europaea, protects cortical neurons against oxygen-glucose deprivation-induced injury”EJP, 2011; 670(1):148–153.
19. Osuna P, “Use of maslinic acid for the treatment of diseases and the symptoms thereof by means of cox-2 inhibition” US Patent US 20110105611A1, 2011.
20. Li C, Yang Z, Li Z et al., “Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-????B and MAPK signaling pathways,” JBMR,2011; 26(3):644–656.
21. Banno N, Akihisa T, Tokuda H, et al., “Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica” BPB, 2005; 28(10):1995–1999
2. Sánchez GM, Lozano MG, Juan ME, García GA, Planas JM, “Assessment of the safety of maslinic acid, a bioactive compound from Olea europaea L” MNFR, 2013; 57:339–346.
3. Tschesche R, Heesch A, Fugmann R, “Über triterpenoide, III. Mitteil.: Zur kenntnis der crataegolsäure” CB, 1953; 86:626‒629.
4. Moneriz C, Mestres J, Bautista JM, Diez A, Puyet A, “Multi-targeted activity of maslinic acid as an antimalarial natural compound” FEBSJ, 2011; 278(16):2951-61.
5. Juan ME,Planas JM,Ruiz GV, Daniel H, Wenzel U, “Anti-proliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells”BrJN, 2008; 100:36–43.
6. Li C,Yang Z, Zhai C, Qiu W, Li D, Yi Z, Wang L, Tang J, Qian M, Luo J,et al, “Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway” MC, 2010; 73(1):73:13.
7. Jamkhande PG, Pathan SK, Wadher SJ,“In silico PASS analysis and determination of antimycobacterial, antifungal, and antioxidant efficacies of maslinic acid in an extract rich in pentacyclic triterpenoids” IJM, 2016;5(4):417–425.
8. Wen X,Sun H,Liu J, Wu G, Zhang L, Wu X, Ni P, “Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases”BMCL, 2005; 15:4944–4948.
9. Wang R, Wang W, Wang L, Liu R,Ding Y,Du L,”Constituents of the flowers of Punica granatum”Fitoterapia, 2006; 77:534–537.
10. Napetschnig J,Wu H, “Molecular basis of NF-κB signaling” ARB, 2013; 42:443–468.
11. Hussain SA, Rasool SN, Abdul KM, Krushna GS, Akhtar PM, Devi KL, “Maslinic acid protects against isoproterenol-induced cardiotoxicity in albino Wistar rats” JMFood, 2012; 15:741–746.
12. Kagansky N,Levy S,Knobler H, “The role of hyperglycemia in acute stroke” AN, 2001;58: 1209–1212.
13. Xu HX, Zeng FQ,Wan M, Sim KY, “Anti-HIV triterpene acids from Geum japonicum” JNP, 1996; 59(7):643–645.
14. Braca A,Morelli I,M´endez J, Battinelli L, Braghiroli L,Mazzanti G, “Antimicrobial triterpenoids from Licania heteromorpha” PM, 2000; 66(8):768–769.
15. Sanchez TS, Reyes ZFJ, Dıaz MS, et al, “Maslinic acid-enriched diet decreases intestinal tumor genesis in ApcMin/+ mice through transcriptomic and metabolomics reprogramming” PLoS ONE, 2013; 8(3):59392.
16. Marquez MA, Puerta Vazquez A, Fernandez Arche,Ruiz GA,“Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages” FRResearch, 2006; 40(3):295–302.
17. Huang TL, Guan Y, Qian et al., “Anti-inflammatory effects of maslinic acid, a natural triterpene, in cultured cortical astrocytes via suppression of nuclear factor-kappa B” EJP, 2011; 672(1–3):169–174.
18. Qian Y, Guan T,Tang X et al., “Maslinic acid, a natural triterpenoid compound from Olea europaea, protects cortical neurons against oxygen-glucose deprivation-induced injury”EJP, 2011; 670(1):148–153.
19. Osuna P, “Use of maslinic acid for the treatment of diseases and the symptoms thereof by means of cox-2 inhibition” US Patent US 20110105611A1, 2011.
20. Li C, Yang Z, Li Z et al., “Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-????B and MAPK signaling pathways,” JBMR,2011; 26(3):644–656.
21. Banno N, Akihisa T, Tokuda H, et al., “Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica” BPB, 2005; 28(10):1995–1999
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Choudhary N, Singh N, Singh AP, Singh AP. Medicinal Uses of Maslinic Acid: A Review. JDDT [Internet]. 15Mar.2021 [cited 20Apr.2021];11(2):237-40. Available from: http://jddtonline.info/index.php/jddt/article/view/4588
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