Emerging Molecular Pathways Involved in Pathophysiology of Cardiac Remodeling

  • Sunny Dhiman School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028
  • Priyankul Palia School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028
  • Pankaj Kumar School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028
  • Shalini Jamwal School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028
  • Chinu Kumari School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

Abstract

Mammalian heart is a dynamic organ that can adapt morphological changes in response to alteration in workload. Various clinical and experimental findings revealed that in response to physiological stimuli or pathological insults, the heart undergoes cardiac remodeling which can be characterized by molecular, cellular or interstitial changes and can be manifested clinically as changes in size, shape and pumping function of the heart. A Sound understanding of changes in hearts cellular and molecular components and to mediators that derive homeostatic control is necessary before a specific intervention is pursued. Summarized data of this review comprises role of various novel emerging molecular pathways involvement in the pathophysiology of cardiac remodeling.


Keywords: Cardiac remodeling, hypertrophy, protein kinase, heart failure, molecular targets, pathological insult.

Keywords: Cardiac remodeling, hypertrophy, protein kinase, heart failure, molecular targets, pathological insult

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Author Biographies

Sunny Dhiman, School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

Priyankul Palia, School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

Pankaj Kumar, School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

Shalini Jamwal, School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

Chinu Kumari, School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

School of pharmacy, Abhilashi University Chailchowk, Mandi, H.P., India -175028

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Dhiman S, Palia P, Kumar P, Jamwal S, Kumari C. Emerging Molecular Pathways Involved in Pathophysiology of Cardiac Remodeling. JDDT [Internet]. 15Mar.2021 [cited 20Apr.2021];11(2):178-87. Available from: http://jddtonline.info/index.php/jddt/article/view/4583