Formulation of Metformin Sustained Release Tablet Using Natural Polymer

  • Mehak Siddiqui Radharaman Institute of Pharmaceutical Science, Bhadbhada Road Ratibad, Bhopal MP 462046 India
  • L. K. Omray Radharaman Institute of Pharmaceutical Science, Bhadbhada Road Ratibad, Bhopal MP 462046 India
  • Pushpendra Soni Radharaman Institute of Pharmaceutical Science, Bhadbhada Road Ratibad, Bhopal MP 462046 India

Abstract

The overall objective of the present work was to develop an oral sustained-release (SR) Metformin tablet that is prepared by the direct compression method by using hydrophilic hydroxyl propyl methyl cellulose (HPMC) and Guar gum polymer alone as well as in combination at different concentrations. Metformin is a biguanide that has a relatively short plasma half-life. It has low absolute bioavailability. All the properties were evaluated for thickness, weight variation, hardness and drug content uniformity and in vitro drug release. The mean dissolution time is used to characterize the drug release rate from a dosage form that indicates the drug release-retarding efficiency of the polymer. The hydrophilic matrix of HPMC alone could not control the Metformin release effectively for 12 h but when combined with Guar gum, it could slow down the release of drug and, thus, can be successfully employed for formulating Sustain Release matrix tablets.


Keywords: Guar gum, hydroxylpropylmethylcellulose, matrix tablets, release kinetics,

Keywords: Guar gum, hydroxylpropylmethylcellulose, matrix tablets, release kinetics

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Author Biographies

Mehak Siddiqui, Radharaman Institute of Pharmaceutical Science, Bhadbhada Road Ratibad, Bhopal MP 462046 India

Radharaman Institute of Pharmaceutical Science, Bhadbhada Road Ratibad, Bhopal MP 462046 India

L. K. Omray, Radharaman Institute of Pharmaceutical Science, Bhadbhada Road Ratibad, Bhopal MP 462046 India

Radharaman Institute of Pharmaceutical Science, Bhadbhada Road Ratibad, Bhopal MP 462046 India

Pushpendra Soni, Radharaman Institute of Pharmaceutical Science, Bhadbhada Road Ratibad, Bhopal MP 462046 India

Radharaman Institute of Pharmaceutical Science, Bhadbhada Road Ratibad, Bhopal MP 462046 India

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Siddiqui M, Omray LK, Soni P. Formulation of Metformin Sustained Release Tablet Using Natural Polymer. JDDT [Internet]. 15Mar.2021 [cited 20Apr.2021];11(2):31-7. Available from: http://jddtonline.info/index.php/jddt/article/view/4579