Hydrodynamically Balanced System: A Review

  • Pawankumar H Yadav Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India
  • Dipak P Kardile Department of Pharmaceutical Chemistry, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India
  • Madhuri T Deshmukh Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India
  • Rajkumar V. Shete Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India

Abstract

The most suitable drug delivery route is oral delivery due to its easily administration, patient adherence/ patient capacitance etc. Several approaches have been made for maximizing the G.R.T such as high-density system, floating system, swelling & expanding system and mucoadhesive & bio adhesive system etc. the main motive of reviewing the article is to focus on the mechanism of HBS system, classification with new system such as raft forming system and hollow microsphere, its application, marketed preparation and evaluation study. The procedure of gastric emptying is a complex and may leads to uncertainty for in vivo performance of the DDS. To prevent this type of complex formation and uncertainty, hard work has been done to expand the retention time of DDS for half of the day. The FDDS are beneficial in such process.


Keywords: HBS system, GRDDS, gastric residence time (G.R.T), raft forming systems, floating formulations, evaluation study. 

Keywords: HBS system, GRDDS, gastric residence time (G.R.T), raft forming systems, floating formulations

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Author Biographies

Pawankumar H Yadav, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India
  1. Pharm Student, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India
Dipak P Kardile, Department of Pharmaceutical Chemistry, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India

Professor, Department of Pharmaceutical Chemistry, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India

Madhuri T Deshmukh, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India

Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India

Rajkumar V. Shete, Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India

Principal, Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy Bhor -412206 Pune Maharashtra India

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Yadav PH, Kardile DP, Deshmukh MT, Shete RV. Hydrodynamically Balanced System: A Review. JDDT [Internet]. 15Feb.2021 [cited 4Mar.2021];11(1-s):147-53. Available from: http://jddtonline.info/index.php/jddt/article/view/4548