A Review on Pediatric Adverse Effects of First Line Anti-Tubercular Drugs
Tuberculosis is a potentially serious communicable disease caused by mycobacterium tuberculosis. That mainly affects lungs. Tricky mitigation and diagnosis cause the childhood tuberculosis a growing burden for society. Directly Observed Treatment Short course (DOTS) strategy is one of the largest public health programmes found to be beneficial against tuberculosis. Anti-tubercular treatment shows greater level of efficacy high degree of toxicity; however combination treatment, especially during the intensive phase of therapy may produce severe adverse events. First line therapy of Tuberculosis leads to serious adverse effects. Serious adverse effects are less in children receiving drug therapy. Major adverse event associated with anti TB drugs is hepatotoxicity.
Keywords: Tuberculosis, DOTS, isoniazid, rifampicin, pyrazinamide, ethambutol and streptomycin
2. Frydenberg AR, Graham SM. Toxicity of first‐line drugs for treatment of tuberculosis in children. Tropical Medicine & International Health. 2009 Nov; 14(11):1329-37.
3. World Health Organization. Guidance for national tuberculosis programmes on the management of tuberculosis in children. World Health Organization; 2014.
4. Thee S, Seddon JA, Donald PR, Seifart HI, Werely CJ, Hesseling AC, Rosenkranz B, Roll S, Magdorf K, Schaaf HS. Pharmacokinetics of isoniazid, rifampin, and pyrazinamide in children younger than two years of age with tuberculosis: evidence for implementation of revised World Health Organization recommendations. Antimicrobial agents and chemotherapy. 2011 Dec 1; 55(12):5560-7.
5. Ramachandran G, Kumar AH, Bhavani PK, Gangadevi NP, Sekar L, Vijayasekaran D, Rekha VB, Kumar SR, Ravichandran N, Mathevan G, Swaminathan S. Age, nutritional status and INH acetylator status affect pharmacokinetics of anti-tuberculosis drugs in children. INT J TUBERC LUNG DIS. 2013; 17(6):800-6.
6. Ramachandran G, Kumar AH, Swaminathan S. Pharmacokinetics of anti-tuberculosis drugs in children. The Indian Journal of Pediatrics. 2011 Apr 1; 78(4):435-42.
7. Graham SM, Bell DJ, Nyirongo S, Hartkoorn R, Ward SA, Molyneux EM. Low levels of pyrazinamide and ethambutol in children with tuberculosis and impact of age, nutritional status, and human immunodeficiency virus infection. Antimicrob Agents Chemother. 2006; 50:407–13.
8. Al-Dossary FS, Ong LT, Correa AG & Starke JR, Treatment of childhood tuberculosis with a six month directly observed regimen of only two weeks of daily therapy. Pediatric Infectious Disease Journal 2002; 21:91–97.
9. Frydenberg A, Graham S. What are the major antituberculous drug toxicities in children?.
10. Arbex MA, Varella MD, Siqueira HD, Mello FA. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs. J Bras Pneumol. 2010 Jun; 36(5):641-56.
11. Corrigan D & Paton J, Hepatic enzyme abnormalities in children on triple therapy for tuberculosis. Pediatric Pulmonology 1999; 27:37–42.
12. Sterling TR, Bethel J, Goldberg S, Weinfurter P, Yun L, Horsburgh CR, Tuberculosis Epidemiologic Studies Consortium. The scope and impact of treatment of latent tuberculosis infection in the United States and Canada. American journal of respiratory and critical care medicine. 2006 Apr 15; 173(8):927-31.
13. Gideon HP, Flynn JL. Latent tuberculosis: what the host “sees”?. Immunologic research. 2011 Aug 1; 50(2-3):202-12.
14. Kabra SK, Lodha R, Seth V. Category based treatment of tuberculosis in children. Indian Pediatr. 2004 Sep; 41(9):927-37.
15. Sharma S, Sarin R, Khalid UK, Singla N, Sharma PP, Behera D. The DOTS strategy for treatment of paediatric pulmonary tuberculosis in South Delhi, India. The international journal of tuberculosis and lung disease. 2008 Jan 1; 12(1):74-80.
16. Arora VK, Gupta R. Directly observed treatment for tuberculosis. The Indian Journal of Pediatrics. 2003 Nov 1; 70(11):885-9.
17. Chauhan LS, Arora VK, Central TB, Directorate General of Health Services M. Management of pediatric tuberculosis under the Revised National Tuberculosis Control Program (RNTCP). Indian pediatrics. 2004 Sep; 41(9):901.
18. Al-Dossary FS, Ong LT, Correa AG, Starke JR. Treatment of childhood tuberculosis with a six month directly observed regimen of only two weeks of daily therapy. The Pediatric infectious disease journal. 2002 Feb 1; 21(2):91-7.
19. Schaaf HS, Thee S, van der Laan L, Hesseling AC, Garcia-Prats AJ. Adverse effects of oral second-line antituberculosis drugs in children. Expert opinion on drug safety. 2016 Oct 2; 15(10):1369-81.
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