Gastroprotective and antioxidant properties of ethanolic extract from pear fruit (Pyrus communis L.)

  • Saliha Djidel Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria
  • Amel Bouaziz Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria
  • Assia Bentahar Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria
  • Seddik Khennouf Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria

Abstract

The objective of this study was to evaluate the phenolic content, in vitro antioxidant activity and the gastroprotective effect of the ethanolic extract of pear fruits (Pyrus communis L.). The amount of polyphenols and flavonoids contents of ethanolic extract were found to be 77,50 ± 2,50 mg GAE/g of dry extract and 0,31 ± 0,003 mg QE/ g of dry extract, respectively. Whereas the amount of tannins was 61,43 ± 0,009 mg TAE/ g of dry extract. Hydroxyl radical scavenging and reducing power tests were used to evaluate the antioxidant activities of this extract. The scavenging effect of ethanolic extract against hydroxyl radicals showed IC50 value of 2.71 ± 0.02 mg/ ml. Reducing power test indicated the ability of ethanolic extract of pear fruits to reduce Fe+2 to Fe+3  with EC50value of 1.043±0.01 mg/ml. The treatment of rats with the ethanolic extract at  dose of 200 mg/kg reduced the ulcerogenic effect of ethanol with value of protection rate of 94.44%, but the protection rate decreased in 600 mg/kg treated group  to 90.17%.  In conclusion, natural antioxidants derived from pear fruits can prevent gastric ulcer through their antioxidant activity 


Keywords: Pyrus communis L., Polyphenols, Antioxidant activity, Ulcer, Rat.

Keywords: Pyrus communis L., Polyphenols, Antioxidant activity, Ulcer, Rat

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Author Biographies

Saliha Djidel, Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria

Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria

Amel Bouaziz, Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria

Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria

Assia Bentahar, Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria

Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria

Seddik Khennouf, Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria

Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, University Ferhat Abbas Setif 1, Setif, 19000, Algeria

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1.
Djidel S, Bouaziz A, Bentahar A, Khennouf S. Gastroprotective and antioxidant properties of ethanolic extract from pear fruit (Pyrus communis L.). JDDT [Internet]. 29Oct.2020 [cited 8Dec.2022];10(5):306-10. Available from: http://jddtonline.info/index.php/jddt/article/view/4538