Immunomodulators in the Treatment of Psoriasis

  • Namitha Maniyan Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India
  • K. Sreejith Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India
  • Cherakkulath C Neena Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India
  • B. Athulnadh Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India
  • P.P. Muhamed Faris Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India
  • K.V. Musaina Thasneem Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India
  • K Gayathri Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

Abstract

Psoriasis is a chronic T lymphocyte mediated systemic inflammatory disease characterised by recurrent exacerbations and remission of thickened, erythematous and scaling plaque and multiple comorbidities. Based on morphology and extend of involvement dermatosis may range from innocuous lesion to wide spread life threatening pustular and erythrodermic forms. Psoriasis is a multifactorial skin disease and it involves a complex pathogenesis. It can be explained by a immunological disregulation of cell function along with differentiation or proliferation of keratinocyte. Psoriasis treatment aims to reduce skin inflammation and to clear skin. Conventional therapy usually includes topical, light and systemic medications. All the three therapies are found to be good for the treatment but are associated with a number of side effects like increased skin sensitivity, burning, skin staining, xerosis and alopecia etc.  Nowadays various recent therapeutic advances are attempting to control the T cell expression by the suppression of same and are correlates with the clinical remission. Immunomodulators and biological therapy contribute a new way for psoriasis therapy. These drugs are more safer, effective and selective immunosuppressive agents as compared to conventional agents. This review summarisesthe variousimmunomodulators used in the treatment of psoriasis


Keywords: Psoriasis, conventional therapy, immunomodulators

Keywords: Psoriasis, conventional therapy, immunomodulators

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Author Biographies

Namitha Maniyan, Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

K. Sreejith, Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

Cherakkulath C Neena, Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

B. Athulnadh, Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

P.P. Muhamed Faris, Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

K.V. Musaina Thasneem, Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

K Gayathri, Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

Departement of pharmacy Practice, College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala-673008, India

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Maniyan N, Sreejith K, Neena C, Athulnadh B, Faris P, Thasneem K, Gayathri K. Immunomodulators in the Treatment of Psoriasis. JDDT [Internet]. 15Nov.2020 [cited 26Nov.2020];10(6):213-5. Available from: http://jddtonline.info/index.php/jddt/article/view/4530