A Review on Gastro-Retentive Floating Microspheres

  • Anuradha A. Birajdar Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune, (M.S) India
  • Madhuri T. Deshmukh Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune, (M.S) India
  • Rajkumar V. Shete Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune, (M.S) India

Abstract

The floating microsphere's purpose is to improve gastric retention time. Floating drug delivery systems are lower in bulk thickness than gastric juice and remain floating on gastric juice for a long period of time without impacting the gastric-emptying rate and increasing bioavailability. Gastro-retentive microspheres are particularly suitable for the continuous or late release of oral formulations with blending versatility to achieve various release patterns, low dose risk as a reproducible and short gastric retention time. The aim of this review is to address literature on the floating device, techniques, selection of suitable or inappropriate drug candidates for GRDDS, low density polymers used to swim over gastric fluid, processes, and floating microsphere assessment and application.


Keywords: GRDDS, Floating system, Approaches, Polymer, Mechanism, Methods

Keywords: GRDDS, Floating system, Approaches, Polymer, Mechanism, Methods

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Author Biographies

Anuradha A. Birajdar, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune, (M.S) India

M Pharm. Student, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune, (M.S) India

Madhuri T. Deshmukh, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune, (M.S) India

Professor, Department of Pharmaceutics, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune, (M.S) India

Rajkumar V. Shete, Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune, (M.S) India

Principal, Department of Pharmacology, Rajgad Dnyanpeeth’s College of Pharmacy, Bhor-412206 Dist-Pune, (M.S) India

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Birajdar AA, Deshmukh MT, Shete RV. A Review on Gastro-Retentive Floating Microspheres. JDDT [Internet]. 15Feb.2021 [cited 4Mar.2021];11(1-s):131-8. Available from: http://jddtonline.info/index.php/jddt/article/view/4518