Evaluation of Anti-Anaphylactic Activity of methanolic extract of Momordica charantia in Experimental Animals
Anaphylaxis is a syndrome that can be fatal, which is seen due to systemic release of inflammatory mediators. Antigen and Antibody reaction is usually a trigger in the body to go into anaphylactic shock. In this study, anaphylaxis induced by egg albumin in the rats. The efficiency of MC (Momordica charantia) against anaphylaxis was evaluated. The standard drug used was Dexamethasone. The MC extract is given in doses 100 and 200 mg/kg p.o.
Results: The MC extract was found to be effective (p<0.01) inhibitor of egg albumin induced anaphylactic reaction.
Conclusion: From this study, we can conclude that Momordica charantia fruits have good anti-anaphylactic activity.
Keywords: Anaphylaxis, Momordica charantia, Egg albumin, Passive paw anaphylaxis, Dexamethasone.
2. Girish, C., and Y. Narsimha Reddy. “Evaluation of Antianaphylactic Activity of Various Extracts of Withania Somnifera in Rats.” International Journal of Pharmaceutical Sciences and Research 2017; 8(4):1717.
3. Suralkar AA, Kasture SB. Anti allergic and anti anaphylactic activities of Dolichos biflorus. International Journal of Green Pharmacy (IJGP). 2013; 7(3).
4. Gupta, Madhu, et al. "Momordica charantia Linn.(Karela): Nature’s silent healer." International Journal of Pharmaceutical Sciences Review and Research 2011; 11(1):32-37.
5. Kumar DS, Sharathnath KV, Yogeswaran P, Harani A, Sudhakar K, Sudha P, Banji D. A medicinal potency of Momordica charantia.
6. Ahamad, Javed, Saima Amin, and S. R. Mir. "Momordica charantia Linn.(Cucurbitaceae): Review on phytochemistry and pharmacology." Phytochemistry 2017; 11(2):53-65.
7. Nkambo, W., N. G. Anyama, and B. Onegi. "In vivo hypoglycemic effect of methanolic fruit extract of Momordica charantia L." African health sciences 2013; 13(4):933-939.
8. Juvekar, Archana Ramesh, et al. "In vitro and in vivo evaluation of immunomodulatory activity of methanol extract of Momordica charantia fruits." Drug Invention Today 2009; 1(2) 89-94.
9. Alam S, Asad M, Asdaq SM, Prasad VS. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. Journal of ethnopharmacology. 2009 Jun 25; 123(3):464-9.
10. A.A. Suralkar, R.G. Kharade, V.R. Bora, Antiallergic, Antianaphylactic & mast cell stabilizing potential of Vitis vinifera in management of Asthma, World J. Pharmaceutica. Res. 2015; 4:1017-1028.
11. Kulkarni, P. A., et al. “Preclinical evaluation of co-administration bronchodilators and corticosteroids for the treatment of asthma.” Res J Pharm Biol Chem Sci 2010; 4:789- 800
12. Patil, S., and P. Ninave. “In-vivo and in-vitro screening models of asthma: an overview.” International Journal of Research and Development in Pharmacy and Life Sciences 2016; 5(4):2209-2218.
13. Alakshmi V, Chandiran R, Velraj M, Hemalatha, Jayakumari. Anti-Anaphylactic and Anti-Inflammatory Activities of a Bioactive Alkaloid from the Root Bark of Plumeria acutifolia Poir. Iran J Pharm Res. 2011; 10(3):525-533.
14. Lee JK, Vadas P. Anaphylaxis: mechanisms and management. Clin Exp Allergy. 2011; 41(7):923-938.
15. Vijayalakshmi A, Ravichandiran V, Velraj M, Hemalatha S, Sudharani G, Jayakumari S. Anti–anaphylactic and anti–inflammatory activities of a bioactive alkaloid from the root bark of Plumeria acutifolia Poir. Asian Pacific journal of tropical biomedicine. 2011 Oct 1; 1(5):401-5.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).