Evaluation of Anti-Anaphylactic Activity of methanolic extract of Momordica charantia in Experimental Animals

  • Shubhangi Dhananjay Deshpande All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O., Pune, Maharashtra, India-411001
  • Swati Kolhe All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O., Pune, Maharashtra, India-411001
  • Sachin Tembhurne All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O., Pune, Maharashtra, India-411001

Abstract

Anaphylaxis is a syndrome that can be fatal, which is seen due to systemic release of inflammatory mediators. Antigen and Antibody reaction is usually a trigger in the body to go into anaphylactic shock. In this study, anaphylaxis induced by egg albumin in the rats. The efficiency of MC (Momordica charantia) against anaphylaxis was evaluated. The standard drug used was Dexamethasone. The MC extract is given in doses 100 and 200 mg/kg p.o.


Results: The MC extract was found to be effective (p<0.01) inhibitor of egg albumin induced anaphylactic reaction.


Conclusion: From this study, we can conclude that Momordica charantia fruits have good anti-anaphylactic activity.


Keywords: Anaphylaxis, Momordica charantia, Egg albumin, Passive paw anaphylaxis, Dexamethasone.

Keywords: Anaphylaxis, Momordica charantia, Egg albumin, Dexamethasone, Passive paw anaphylaxis

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Author Biographies

Shubhangi Dhananjay Deshpande, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O., Pune, Maharashtra, India-411001

All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O., Pune, Maharashtra, India-411001

Swati Kolhe, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O., Pune, Maharashtra, India-411001

All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O., Pune, Maharashtra, India-411001

Sachin Tembhurne, All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O., Pune, Maharashtra, India-411001

All India Shri Shivaji Memorial Society’s College of Pharmacy, Kennedy Road, Near R.T.O., Pune, Maharashtra, India-411001

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Deshpande S, Kolhe S, Tembhurne S. Evaluation of Anti-Anaphylactic Activity of methanolic extract of Momordica charantia in Experimental Animals. JDDT [Internet]. 15Oct.2020 [cited 21Oct.2020];10(5-s):149-51. Available from: http://jddtonline.info/index.php/jddt/article/view/4506