As Review on Microsponge Gel as Topical Drug Delivery System

  • Pravin Jamnadas Kshatriya Department of Pharmaceutics, PDEA’s S.G.R.S. College of Pharmacy, Saswad, India
  • Jitendra V. Shinde Department of Pharmaceutics, PDEA’s S.G.R.S. College of Pharmacy, Saswad, India
  • Rajashree S. Chavan Pune District Education Association’s Seth Govind Ragunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India

Abstract

Microsponges are drug delivery systems composed of porous microspheres. They are little sponge – like spherical particles with an outside surface porous surface. Moreover, they will enhance stability, scale back aspect effect and modify drug unharness favourably. Microsponge technology has several favorable characteristics that make it a flexible drug delivery vehicle. Microsponge  system square measure supported microscopic, chemical compound based mostly microspheres that may suspend or entrap a good type of substances, and might may be incorporated into a developed product like a gel, cream, liquid, powder. The outer surface is often porous, permeating a sustained flow of drugs out of sphere. Microsponges square measure porous, compound microspheres that square measure used principally for typical use and have recently been used for oral administration. microsponge  square measure designed to deliver a pharmaceutical active ingredient with efficiency at the minimum dose and additionally to reinforce solubility, scale back aspect effects and modify drug unharness.


Kyewords: Controlled release, drug delivery, care systems, microponges.

Keywords: Controlled unharness, drug delivery, care systems, microponges

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Author Biographies

Pravin Jamnadas Kshatriya, Department of Pharmaceutics, PDEA’s S.G.R.S. College of Pharmacy, Saswad, India

Department of Pharmaceutics, PDEA’s S.G.R.S. College of Pharmacy, Saswad, India

Jitendra V. Shinde, Department of Pharmaceutics, PDEA’s S.G.R.S. College of Pharmacy, Saswad, India

Department of Pharmaceutics, PDEA’s S.G.R.S. College of Pharmacy, Saswad, India

Rajashree S. Chavan, Pune District Education Association’s Seth Govind Ragunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India

Pune District Education Association’s Seth Govind Ragunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, India

References

1] Won R. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredients as a porogen. Patent No. 4690825. US;1987.
2] Chowdary KP, Rao YS. Mucoadhesive microspheres for controlled drug delivery. Biol Pharm Bull2004; 27(11):1717-24.
3] Embil K, Nacht S. The Microsponge Delivery System (MDS): A topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives. J Microencapsul 1996; 13(5):575-88.
4] Nachit S, Kantz M. The microsponge: A novel topical programmable delivery system. Top Drug Deliv Syst1992; 42:299-325.
5] Chadawar V, Shaji J. Microsponge delivery system. Curr Drug Deliv 2007; 4(2):123-9.
6] Newton DW. Biotechnology frontier: Targeted drug delivery. US Pharmacist1991; 16:36-52.
7] Delattre L, Delneuville I. Biopharmaceutical aspects of the formulation of dermatological vehicles. J Eur Acad Dermatol Venereol 1995; 5:70-1.
8] Viral S, Jain H, Krishna J, Patel P. Microsponge drug delivery system: A review. Int J Res Pharm Sci2010; 1(2):212-8.
9] Yang L, ChuJ S, Fix JA. Colon-specific drug delivery: New approaches and in vitro/in vivo evaluation. Int J Pharm2002; 235(1-2):1-15.
10] Kydonieus AF, Berner B. Transdermal Delivery of Drugs. Vol. 261. Boca Raton: CRC Press; 1987. p.52-65.
11] Vyas SP, Khar RK. Targeted and Controlled Drug Delivery-Novel Carrier System. 1st ed. New Delhi: CBS Publication; 2002. p.453-1.
12] Namrata J, Patel V, Mungekar S, Karpe M, Kadam V. Microsponge delivery system: An updated review current status and future prospects. World J Pharm Pharm Sci2007; 2(6):6463-85.
13] Aritomi H, Yamada K, Honda H, Koshi M. Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. J Pharm Sci Technol1996; 56(1):49-56.
14] D’souza JI, Masvekar RR, Pattekari PP,Pudi SR, More HN. Microspongic delivery of fluconazole for topical application. Indo- Japanese Int Conf Adv Pharm Res Technol2004; 456:76-81.
15] Partibhan KG, Manivannan R. Krishnarajan D, Chandra S, Raj N. Microsponges role in Novel drug delivery. Int J Pharm Res Dev 2011; 3(4):117-1258.
16] Soni M, Saxena C, Soni P, Sharma DK. Microsponge: A versatile vesicular approach for Transdermal drug delivery system. J Global Pharm Tech2010; 2(3):154-64.
17] Aloorkar NH, Kulkarni AS, Ingale DJ, Patil RA. Microsponges as Innovative drug delivery systems. Int J pharm Sci Nonotechnol 2012; 5(1):143-151.
18] D’souza JI. The microsponge drug delivery system: For delivering an active ingredient by controlled time release. Pharmainfo. Net 2008; 6(3):47-62.
19] Patravale VB. Microsponges: A path-breaking cosmetic innovation. Emerging Technol Household Personal Care Today2008; 4:45-9.
20] Pradhan SK. Microsponges are as the versatile tool for drug delivery system. Int J Res Pharm Chem2011;40(1):196-201.
21] Kawashima Y, Niwa T, Takeuchi H, Hino T, Ito Y. Control of prolonged drug release and compression properties of ibuprofen microspheres with acrylic polymer, eudragit RS, by changing their intraparticle porosity [corrected]. Chem Pharm Bull (Tokyo)1992; 40(1):196-201.
22] Wester RC, Patel R, Nacht S, Leyden J, Melendres J, Maibach H. Controlled release of benzoyl peroxide from a porous microsphere polymeric system can reduce topical irritancy. J Am Acad Dermatol 1991; 24:720-6.
23] Santanu K, Sabyasachi M, Ghosh KA, Banerjee S. Micrsponge: A noval strategy for drug delivery system. J Pract Technol Res 2011; 5(2):243-28.
24] Brunton LL, Lazo JS, Parker KL. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 11th ed., Vol. 2. New York: McGraw-Hill; 2006. p.1021-7.
25] Vikrant K, James S, Anne J and Manish SK. Microparticles: A novel approach to enhance the drug delivery. Int J Pharm Res Dev 2011; 3(8)170-83.
26] Jain N, Sharma PK, Banik A. Recent advances in mirosponges drug delivery system. IJPSRR2011; 342:13-4.
27] Kilicarslan M, Baykara T. The effect of drug & polymer ratio on the properties of the Verapamil hydrochloride loaded microspheres. Int J Pharm2003; 252:99-109.
28] Mine O, Erdal C. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J of Pharm 2006; 318:103-117.
29] Martin A, Swarbrick J, Cammarrata A. In: Physical Pharmacy & Physical Chemical Principles in Pharmaceutical Sciences. Vol.3. New Delhi, India: B. I. Waverly; 1991. p.527-36.
30] Vyas LK, Tapar KK, Laddha BH, Lahoti AO, Nema RK. Formulation and development of anti-blemish preparation using microsponge technology. J Chem Pharm Res2010; 2(5):562-71.
31] Ruckenstein E, Hong L. Concentrated emulsion polymerization pathway to hydrophobic and hydrophilic microsponge molecular reservoirs. Chem Mater1992; 4:1032-7.
32] Zaki Rizkalla CM, latif Aziz R, Soliman II. In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. AAPS Pharm Sci Tech2011; 12(3):989-1001.
33] Shah VP. Determination of in-vitror elease from hydrocortisone creams. Int J Pharm1989; 53:53-9.
34] Christensen MS, Hargens CW rd, Nacht S, Gans EH. Viscoelastic properties of intact human skin: Instrumentation, hydration effects, and the contribution of the stratum corneum. J Invest Dermatol 1977; 69(3):282-6.
35] Sato T, Kanke M, Schroeder HG, DeLuca PP. Porous biodegradable microspheres for controlled drug delivery. I. Assessment of processing conditionsandsolventremovaltechniques.PharmRes1988; 5(1):21-30.
36] Guyot M, Fawaz F. Microspheres preparation and physical characteristics. Int J Pharm1998; 175:61-74.
37] Kaity S, Maiti S, Ghosh AK, Pal D, Ghosh A, Banerjee S. Microsponges: A novel strategy for drug delivery system. J Adv Pharm Technol Res 2010; 1(3):283-90.
38] Roaa AN, Hussein AA. Preparation and evaluation of meloxicam microsponges as transdermal delivery system. Iraqi J Pharm Sci 2014; 23(2):62-74.
39] Anilkumar JS, Mano B, Sawant SS. Development and evaluation of fenoprofen microsponges and its colonic delivery using natural polysaccharides.IntPublAmJPharmSciNanotechnol2014;1(1):27-42.
40] Markhand M, Amish P, Viral HS, Upadhyay U. Formulation and in- intro evaluation of release microsponge gel for topical delivery of clotrimazole. Int J Adv Pharm2012; 2:93-101.
41] Makwana R, Patel H, Petal V, Photostability enhancement of miconazole nitrate by microsponge formulation. Int J Curr Trends Pharm Res2014; 2(3):437-58.
EmanueleAD,DinarvandR.Preparationcharacterizationand drug release from thermo responsive microspheres. Int J Pharm 1995; 118:237-45.
42] Shah V, Jain H, Jethva K, Patel P. Microsponge drug delivery an overview. Int J Res Pharm Sci2010; 1(2):212-8.
43] HarinathN,D’SouzaIJ.Topicalanti-inflammatorygelsoffluocinolone acetonide entrapped in eudragit based microsponge delivery system. Res J Pharm Technol2008; 1(4):72-9.
44] Mohan KV, Veena NM, Manjula BP. Formulation and evaluation of microsponges for topical drug delivery of Mupirocin. Int J Pharm Technol Res2013; 5(2):1434-40.
45] P yadav, S Nanda. Department and evaluation of some microsponge loaded medicated topical formulation of acyclovir. Int J Pharm Sci Res 2014; 5:1395-410 .
46] Rajurkar VG, Tambe AB, Deshmukh VK. Topical anti-inflammatory gels of Naproxen entrapped in eudragit based microsponge delivery system. Adv Chem Engg2015; 5(2):251-8.
47] Chandramoul Y, Firoz S, Rajalakshmi R, Vikram A, Yasmeen RB, Chakravarthi RN. Preparation and evaluation of microsponge loaded controlled release topical gel of acyclovir sodium. Int J Biopharm 2012; 3(2):96-102.
48] Panday P, Shukla N, Sisodiya D, Jain V, Mahajan SC. Design and characterization of microsponge loaded controlled releaseepicutaneous gel of lornoxicam. Appl Med Res2015; 3(2):16-20.
49] Wakiyama N, Juni K, Nakano M. Preparation and evaluation invitro of polylactic acid microspheres containing local anesthetics. Chem Pharm Bull (Tokyo)1981; 29(11):3363-8.
50] Khopade AJ, Jain S, Jain NK. The microsponge. Eastern Pharmacist 1996; 6(3):49-53.
51] Jelvehgari M, Siahi-Shadbad MR, Azarmi S, Martin GP, Nokhodchi A. The microsponge delivery system of benzoyl peroxide: Preparation, characterizationandreleasestudies.IntJPharm2006; 308(1-2):124-32.
52] Amrutiya N, Bajaj A, Madan M. Development of microsponges for topical delivery of mupirocin.AAPS PharmSciTech 2009; 10(2):402-9.
53] Fincham AE, Kamik KA. Patient counseling and derm therapy. US Pharm1994; 19:56-7.
54] Embil VP.OTC External analgesic cream, topical analgesic-anti- inflammation, counterirritant utilizing the microsponge delivery system (MDS) for controlled release of actives Patent Application No: 0101058;UK-2000.
55] Comoglu T, Gönül N, Baykara T. Preparation and invitro evaluation of modified release ketoprofen microsponges. Farmaco 2003; 58(2):101-6.
56] Hibab A, Shaimaa MB. Microsponge as promising vehicle for drug deliver and targeting preparation, characterization and application. Afr J Pharm Pharm2013; 7(17):873-81.
57] Jain V, Singh R. Dicyclomine loaded eudragit based microsponge with potential for colonic delivery: Preparation and characterization. Trop J Pharm Res2010; 9(1):67-72.
58] Jain V, Singh R. Development and characterization of eudragit RS100 loaded microsponges and its colonic delivery using natural polysaccharides. Acta Pol Pharm 2010; 67(4):407-15.
59] Mishra KM, Shikhri M, Sharma R, Goojar MP. Optimization, formulation development and characterization of Eudragit RS 100 loaded microsponges and subsequent colonic delivery. Int J Drug Discov Herbal Res2011; 1(1):8-13.
60] Jain NK, Sharma SN. A Textbook of Professional Pharmacy. 4th ed. New Delhi: Vallabh Prakashan; 2006. p.257-72.
61] Shyam SM, Vedavathi T. Novel approach microsponge drug delivery system. Int J Pharm Sci Res2012; 1(3):967-80.
62] Srivastava R, Pathak K. Microsponges: A futuristic approach for oral drug delivery. Expert Opin Drug Deliv2012; 9(7):863-78.
63] Rossi S, Buckley N. Australian Medicines Handbook. Adelaide: Australian Medicines Handbook Pvt., Ltd.; 2006. p.3572-9.
64] Baselt R. Disposition of Toxic Drugs and Chemicals in Man. 8thed. Foster City: Biomedical Publications; 2008. p.29-31.
65] Gangadharappa HV, Gupta NV, Prasad MS, Shivakumar HG. Current trends in microsponge drug delivery system. Curr Drug Deliv 2013; 10(4):453-65.
66] Trotta F, Cavalli R, Tumiatti W. Cyclodextrin-based nanosponges for drug delivery. J Incl Phenom Macrocycl Chem2006; 56:209-13.
67] Hu SH, Liu TY, Liu DM, Chen SY. Nano-ferrosponges for controlled drug release. J Control Release 2007; 121:181-9.
68] Li NH, Benson JR, Kitagawa N. Polymeric microbeads and method of preparation. International Publication No. WO1995033553; 2003.
69] Lee JB, Hong J, Bonner DK, Poon Z, Hammond PT. Self-assembled RNA interference microsponges for efficient siRNA delivery. Nat Mater2012; 11(4):316-22.
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Kshatriya PJ, Shinde JV, Chavan RS. As Review on Microsponge Gel as Topical Drug Delivery System. JDDT [Internet]. 15Dec.2020 [cited 21Jan.2021];10(6-s):125-33. Available from: http://jddtonline.info/index.php/jddt/article/view/4455