A Review on Carissa carandas: Traditional Use, Phytochemical Constituents, and Pharmacological properties

  • Saurabh Vilas Bhosale Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India
  • Rajkumar V. Shete Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India
  • Vishal S Adak Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India
  • Krishna Murthy Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India

Abstract

Carissa carandas  l. (Karaunda) is a widely useful food and medicinal plant of India, Plant-based medicines play an important role in all cultures have been indispensable in maintaining health and combating diseases. Owing to the global trend towards better quality of life, there is a great claim for medicinal plants. Carissa carandas  l. plant popularly used as a traditional medicinal plant over thousands of years in the Ayurvedic, Unani, and Homoeopathic system of medicine. The major bioactive elements, which impart the medicinal worth of herbs, are alkaloids, flavonoids, saponins, and huge amounts of cardiac glycosides, triterpenoids, phenolic compounds, and tannins. Traditionally, the whole plant and its parts were used in the treatment of various ailments. It contains several phytochemical constituents belonging to the terpenoids category. The root is attributed to bitter, stomachic; antidiarrheal, vermifuge, and ant anthelmintic properties. The medicinally unripe fruit is used as an astringent. The ripe fruit is taken as an antiscorbutic and therapy for nausea. The leaf decoction is appreciated in cases of alternating fever, diarrhea, oral inflammation, and earache. Also, Carissa carandas  have showing a extensive range of evidence for its cardiotonic, hepatoprotective, free radical scavenging and xanthine oxidase inhibitory, histamine-releasing, antirheumatic, antibacterial, antiviral, and anticonvulsant activity. A higher gross heat value of this species indicates its higher potential to be used as a good fuel source.


Keywords: Carissa carandas , Phytochemical Constituents, Traditional Use, Pharmacological Properties.

Keywords: Carissa carandas, Phytochemical Constituents, Traditional Use, Pharmacological Properties

Downloads

Download data is not yet available.

Author Biographies

Saurabh Vilas Bhosale, Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India

Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India

Rajkumar V. Shete, Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India

Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India

Vishal S Adak, Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India

Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India

Krishna Murthy, Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India

Dept. of Pharmacology, Rajgad Dnyanpeeths college of Pharmacy, Bhor, Pune, Maharashtra, India

References

1) Singh A, Uppl GK, A Review on Carissa carandas - phytochemical, ethno-Pharmacology and Micropropagation as conservation stratergy, Asian Journal of Pharmaceutical and Clinical Research, 2015; 8(3):54-60.
2) Bint-e-sadek Y, Choudhary N and Shahriar M, Biological Investigation of the leaf extract of Carissa carandas, International Journal of Pharmacy Research and Technology, 2013; 5(2):97-105
3) Maheshwari R, Sharma A, and Verma D, Phyto-therapeutic significance of karaunda, Bulletin of Environment, Pharmacology and Life Science, 2012; 1(12):34-36.
4) Sawant RS, Comparative studies of Phytochemical screening of Carissa carandas liin., Asian Journal Of Plant Science and Research, 2013; 3(1):21-25
5) Devmurari V, Shivanand P, Goyani MB, Vaghani S, Jivani NP, A Review: Carissa Congesta Phytochemical constituents, Traditional Use and Pharmacological propertices, Pharmacological Review, 2009; 3(6):375-377.
6) Malik SK, Chaury R, Dhariwaln OP, Bhandari DS, Genetic Resource of Tropical Underutilized Fruits in India, National Bureau of Plant Genetic Resources, 2010:178.
7) Maheshwari R, Sharma A, and Verma D, Phyto-therapeutic significance of karaunda, Bulletin of Environment, Pharmacology and Life Science, 2012; 1(12):34-36.
8) Hedge K, Thakker SP, Joshi AB, Shastry CS, Chandrashekhar KS, Anticonvalsant activity of Carissa carandas Linn root extract in experimental mice, Tropical Journal of Pharmaceutical Research, 2009; 8(3):117-125.
9) Rastogi RC, Vohra MM, Rastigi RP, Dhar ML, Studies on Carissa carandas Linn. Part I. Isolation of cardiac activity Principle, Indian Journal of Chemistry, 1966; 4(5):132.
10) Shailajan S, Sayad N, Tiwari B, Biomarker Based Quality Control Method for Carissa carandas Linn. Fruits Using HPTLC Tech, International Journal of Resent Advances in Pharmaceutical Research, 2013; 3(2):33-37.
11) Evans WC, Trease and Evan’s Textbook of Pharmacognosy 13th Ed Cambidge University Press, London, 1989:546.
12) Saha R, Hossain L, Utpat B, Ahmed AR, Neuropharmacological And Diuretic activities of Carissa carandas linn., Leaf Pharmacology online, 2010; 2:320-327.
13) Rana S, Prakash V, Sagar A, Review on medicinal and antioxidant properties of some medicinal plants, Journal of Drug Delivery and Therapeutic, 2016; 6:1-6.
14) Agarwal T, Sing R, Shukla AD, Waris I, In vitro study of antibacterial activity of Carissa carandas leaf extract in rats, Journal of Pharmaceutical, Chemical and Biological Science, 2012; 1:18-25.
15) Addis G, Abebe D, Urga K, A Survey of traditional medicinal plant in shirka district, Arsizone Ethiopian Pharmacutical Journal, 2001; 19:30-47.
16) Kumar V, Tarpada P, Sadariya K, Goswami S, Comparative Phytochemical and Antioxidant activity of methanol And Petroleum Ether Extract of Carissa carandas leaves, fruit and seed, Vivechan International Journal of Research, 2017; 8(2):70-75.
17) Khatun M, Habib MR, Rabbi MA, Amin R, Islam MF, Nurujjaman M, Karim MR, Rahman MH, Antioxidant, Cytotixic and Antineoplastic effect of Carissa carandas Linn. Leaves, Experimental and Toxicology Pathology, 2017 :465-476.
18) Hati M, Jena BK, Nayak AK, Evaluation of anti-inflammatory and anti-pyretic activity of Carissa carandas leaf extract in rat, Journal of Pharmaceutical Chemical and Biological Sciences, 2014; 1(1):18-25.
19) Bhaskar VH, Balkrishnan N, Analgesic, Anti-inflammatory and antipyretic activity of pergularia daemia and Carissa carandas , Journal of Pharmaceutical Sciences, 2009; 17(3):168-174.
20) Itankar PR, Lokhande SJ, Verma PR, Arora SK, Antidiabetic potential of unriped Carissa carandas linn fruit extract, Journal of Ethnopharmacology, 2011; (135):430-433.
21) Swami G, Nagpal N, Rahar S, Singh P, Porwal A, Nagpal MA, And Kopoor R , Effect of Aqueous extract of Carissa carandas linn on blood glucose level of normoglycemic and alloxan induced diabetic wister Rats, International Journal of current Pharmaceutical Research, 2010; 2(3):65-67.
22) Dua D, Srivastav NS, Anti-cancerous and antioxidant potential of aqueous extracts of Annona reticulata, Podophyllum peltatum, Psidium guajava, Ananas comosus, Carissa carandas on MCF-7 cancer cell line, International Journal Integr Science Innovation Technology Science, 2013; 2(4):15-19.
23) David M and Karekalammanavar G. Spectrographic analysis and in vitro study of antibacterial, anticancer activity of aqueous ethanolic fruit extract of Carissa carandas , Journal of Advanced Scientific Research, 2015; 6(3):10-13.
24) Hegde K, Joshi AB, Hepatoprotective effect of Carissa carandas Linn root extract against CCl4 and paracetamol induced hepatic oxidative stress, Indian Journal of Experimental Biology, 2009; 47(8):660-7.
25) Vohra M M, De N N, “Comparative cardiotonic activity of Carissa carandas {L}. and Carissa spinarum {A}, Indian Journal of Medical Research, 1963; 51(5):937-940.
26) Alikeramat SS, Malek MA, Islam K, Salamatullah K, “The food values of indigenous foods Institute of food and Nutrition, Dhaka University, Bangladesh, 1977 :15.
27) Mishra CK, Sasmal D, Shrivastava B, An in vitro evaluation of the anthelmintic activity of unripe fruits extract of Carissa carandas Linn, International Journal of Drug Devlopment and Research, 2012; 4(4):393-7.
28) Verma S, Chaudhary HS, Effect of Carissa carandas against Clinically Pathogenic bacterial strains, Journal of Pharmacy Research. 2011; 4: 3769–3771.
29) Saha R, Hossian L, Neuropharmacological and Diuretic activity of Carissa carandas Linn. Leaf, Pharmacologyonline, 2010; 2: 320-327.
30) Bapna S, Ramaiya M, Chowdhary A, Antimalarial activity of Carissa carandas Linn. against Plasmodium falciparum, Jouranal of Antimicrobial Photon, 2013; 128: 246-50.
Statistics
48 Views | 29 Downloads
How to Cite
1.
Bhosale SV, Shete RV, Adak V S, Murthy K. A Review on Carissa carandas: Traditional Use, Phytochemical Constituents, and Pharmacological properties. JDDT [Internet]. 15Dec.2020 [cited 21Jan.2021];10(6-s):145-50. Available from: http://jddtonline.info/index.php/jddt/article/view/4443