In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

  • Fatima Eram Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India
  • , Vivek Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

Abstract

Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis.


Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid.


Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e.  >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis).


Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis.


Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

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Author Biographies

Fatima Eram, Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

, Vivek, Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

Department of Pharmacy, IIMT College of Pharmacy, Greater Noida, G.B Nagar, U.P., India

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Eram F, Vivek ,. In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery. JDDT [Internet]. 15Oct.2020 [cited 21Oct.2020];10(5-s):32-9. Available from: http://jddtonline.info/index.php/jddt/article/view/4421