Multiple Unite Pellet Systems (MUPS) as Drug Delivery model
Multiparticulate drug delivery systems are mainly oral dosage form, consist of small discrete units that exhibit different characteristics especially in release pattern and drug bioavailability. These systems are represented by granules, pellets, microspheres, microcapsules, and minitablets. Pellets offer high flexibility in the design, formulation, and development of oral dosage forms such as sachet, suspension, capsule, and tablet. Multiparticulate tablets manufactured by compaction of multiple unite pellets is one of the latest and, yet, challenging technologies. Multiparticulate tablets combine the benefits of both a tablet and a pellet-filled capsule in one dosage form but their manufacturing experience many difficulties. The oral multiparticulate products consist of polymer-coated subunits or pellets, which are embedded in an inert excipients’ matrix, formulated to overcome the difficulty in administering capsules and improve the physicochemical stability of suspension and offer predictable release and uniform distribution in the gastro-intestinal tract compared to the plain tablet. This review discusses the advantages and drawbacks of MUPS, the properties of an ideal MUPS, various pharmaceutical applications of MUPS, the challenges and key variables that to be considered in the tableting process for successful production of MUPS
Keywords: MUPS®, Pellets, Multiparticulate tablets.
2. Kumar P, Maravaniya J, Deshpande TM, Shinde RV, Katedeshmukh RG. Multiple unite Pellet System – A New Path for drug delivery. International Journal of Universal Pharmacy and Biosciences. 2013; 2(4):401-415.
3. Patel HP, Patel JK, Patel RR, Patel MP. Pellets: A General Overview. International Journal of Pharma World Research. 2010; 1(2).
4. Jagan MK., Venkatesham A., Chandra ME., Vasu K, Kiran Kumar J., Pelletization Techniques for Oral Drug Delivery. International Journal of Pharmaceutical Sciences and Drug Research 2009; 1(2):63-70.
5. Sirisha K, Kvijaya Sri, K Suresh, G. Kamahkar Reddy. Multiple Unite pellet Systems: A review. International Journal of Pharmacy. 2012; 2(2):419-425.
6. V.S.N. Murthery Dwibhashyma, J. Vijaya Ratna. Key formulation variables in tableting of coated pellets. Indian J. Pharm. Sci. 2008; 70(5):555-564.
7. Dukic-Ott A., Thomas De B., Jean Paul R., Willy B., Paul F., Chris V., In-Vitro and In-Vivo Evaluation of Enteric-Coated Starch-Based Pellets Prepared Via Extrusion/Spheronisation.
European Journal of Pharmaceutics and Biopharmaceutics 2008 Volume 70(1):302-312.
8. Mircea Hirjau, Anca Cecilia N., Victoria Hirjau, D. Lupulease, Pelletization Techniques Used in Pharmaceutical Fields. Practica Farmaceutica 2011; 4; 3-4.
9. Hiren P. Patel, J. K. Patel, Ravi R. Patel, Manish P. Patel, PELLETS: A GNERAL OVERVIEW. International Journal of Pharma World Research, 2010; 1(2).
10. Kumar V, Mishra SK., Lather AV, Singh R. Multiple Unit Dosage Form-Pellet and Pelletization Techniques: An Overview. International Journal of Research in Ayurveda & Pharmacy 2011; 2(1):121-125.
11. Sharma A, Chaurasia S. Multiparticulate Drug Delivery System: Pelletization through Extrusion and Spheronization. International Research Journal of Pharmacy 2013; 4(2).
12. Sirisha VR, Vijaya Sri K, Suresh K, Reddy GK, Devanna N. A Review of Pellets and Pelletization Process – A Multiparticulate Drug Delivery System. International Journal of Pharmaceutical Sciences and Research 2013; Vol. 4(6):2145-2158.
13. Gandhi B, Baheti J. Multiparticulates Drug Delivery Systems: A Review. International Journal of Pharmaceutical and Chemical Science, 2013; 2(3).
14. Jawahar N, Patel HA. Multi-Unit Particulates Systems (MUPS): A Novel Pellets for Oral Dosage Forms. Journal of Pharmaceutical Science and Research. 2012; 4(9):1915-1923.
15. Punia S, Bala R, Rana AC. Pelletization Techniques: A Literature Review. Internal Research Journal of Pharmacy 2012; 3(3).
16. Deb R, Ahmed AB. Pellets and Pelletization Techniques: A Critical Review. International Research Journal of Pharmacy 2013; 4(4).
17. Pathik KJ. M., Tanvee MD, Rohit VS., Ramesh GK. Multiple Unit Pellet System – A New Path For Drug Delivery. International Journal of Universal Pharmacy and Bio Sciences 2013; 2(4).
18. Sirisha VR, Vijaya Sri K, Suresh K, Reddy KG. Multiple Unit Pellet Systems: A Review. International Journal of Pharmacy 2012; 2(2): 419-425.
19. Mangesh EB., Shajahan A, Sunil B J., Anil VC., Jayesh MJ., Dinesh MS. MUPS Tablets – A Brief Review. International Journal of Pharm Tech Research 2010; 2(1):847-855.
20. Reddy S, Das P, Ghosh A. MUPS (Multiple Unit Pellet System) Tablets – A Brief Review. Journal of Pharmaceutical and Biomedical Sciences 2011; 12(12).
21. Bhad ME, Abdul S, Jaiswal SB, Chandewar AV, Jain JM, Sakarkar DM. MUPS Tablets – A Brief Review. International Journal of Pharm Tech Research. 2010; 2(1):847-852.
22. Ozarde YS., Serri S , Polshettiwar SA., Kuchekar BS. Multiple-Unit-Pellet System (MUPS): A Novel Approach for Drug Delivery. Drug Invention Today, 2012; 4(12):603-609.
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